Risk Score based on microRNA expression signature is
independent prognostic classifier of glioblastoma patients

J 2014

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS et. al.

Basic information

Original name

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Authors

ŠÁNA, Jiří (203 Czech Republic, belonging to the institution), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Andrej BEŠŠE (703 Slovakia, belonging to the institution), Jana NEKVINDOVÁ (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Radim JANČÁLEK (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic, belonging to the institution), Marian HAJDÚCH (203 Czech Republic), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution), Rostislav VYZULA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Carcinogenesis, Oxford, Oxford University Press, 2014, 0143-3334

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.334

RIV identification code

RIV/00216224:14740/14:00077330

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1093/carcin/bgu212

UT WoS

000345836200015

Keywords (in Czech)

mikroRNA; expresní profilování; multiformní glioblastom; risc skóre; prognostický klasifikátor

Keywords in English

microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier

Abstract

V originále

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13514, research and development project

Name: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

Files attached

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Citovat

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA and Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. Carcinogenesis. Oxford: Oxford University Press, 2014, vol. 35, No 12, p. 2756-2762. ISSN 0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgu212.

@article{1206178,
   author = {Šána, Jiří and Radová, Lenka and Lakomý, Radek and Křen, Leoš and Fadrus, Pavel and Smrčka, Martin and Bešše, Andrej and Nekvindová, Jana and Hermanová, Markéta and Jančálek, Radim and Svoboda, Marek and Hajdúch, Marian and Šlampa, Pavel and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {Oxford},
   article_number = {12},
   doi = {http://dx.doi.org/10.1093/carcin/bgu212},
   keywords = {microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier},
   language = {eng},
   issn = {0143-3334},
   journal = {Carcinogenesis},
   title = {Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients},
   volume = {35},
   year = {2014}
}

TY  - JOUR
ID  - 1206178
AU  - Šána, Jiří - Radová, Lenka - Lakomý, Radek - Křen, Leoš - Fadrus, Pavel - Smrčka, Martin - Bešše, Andrej - Nekvindová, Jana - Hermanová, Markéta - Jančálek, Radim - Svoboda, Marek - Hajdúch, Marian - Šlampa, Pavel - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2014
TI  - Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
JF  - Carcinogenesis
VL  - 35
IS  - 12
SP  - 2756-2762
EP  - 2756-2762
PB  - Oxford University Press
SN  - 01433334
KW  - microRNA
KW  - expression profiling
KW  - glioblastoma multiforme
KW  - risc score
KW  - prognostic classifier
N2  - Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.
ER  -

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA and Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2014, vol.~35, No~12, p.~2756-2762. ISSN~0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgu212.

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