Identifying craniofacial features associated with prenatal
exposure to androgens and testing their relationship with brain
development

J 2015

Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development

MAREČKOVÁ, Klára; Mallar M. CHAKRAVARTY; Claire LAWRENCE; Gabriel LEONARD; Daniel PERUSSE et. al.

Základní údaje

Originální název

Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí); Mallar M. CHAKRAVARTY (124 Kanada); Claire LAWRENCE (124 Kanada); Gabriel LEONARD (124 Kanada); Daniel PERUSSE (124 Kanada); Michel PERRON (124 Kanada); Bruce G. PIKE (124 Kanada); Louis RICHER (124 Kanada); Suzanne VEILLETTE (124 Kanada); Zdenka PAUSOVÁ (124 Kanada) a Tomáš PAUS (124 Kanada)

Vydání

Brain Structure and Function, Heidelberg, Springer- Verlag Berlin Heidelberg, 2015, 1863-2653

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.811

Kód RIV

RIV/00216224:14740/15:00082167

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1007/s00429-014-0852-3

UT WoS

000361566000010

EID Scopus

2-s2.0-84942374112

Klíčová slova anglicky

Adolescents; Brain; Face; MRI; Prenatal androgens; Twins

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2016 16:50, Martina Prášilová

Anotace

V originále

We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d = 0.76). Subsequently, we tested the possibility that this craniofacial "signature" of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n = 462), we found that the facial signature predicts up to 8 % of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. © 2014 Springer-Verlag Berlin Heidelberg.

Návaznosti

EE2.3.30.0009, projekt VaV

Název: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci

Citovat

MAREČKOVÁ, Klára; Mallar M. CHAKRAVARTY; Claire LAWRENCE; Gabriel LEONARD; Daniel PERUSSE; Michel PERRON; Bruce G. PIKE; Louis RICHER; Suzanne VEILLETTE; Zdenka PAUSOVÁ a Tomáš PAUS. Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. Brain Structure and Function. Heidelberg: Springer- Verlag Berlin Heidelberg, 2015, roč. 220, č. 6, s. 3233-3244. ISSN 1863-2653. Dostupné z: https://doi.org/10.1007/s00429-014-0852-3.

@article{1209759,
   author = {Marečková, Klára and Chakravarty, Mallar M. and Lawrence, Claire and Leonard, Gabriel and Perusse, Daniel and Perron, Michel and Pike, Bruce G. and Richer, Louis and Veillette, Suzanne and Pausová, Zdenka and Paus, Tomáš},
   article_location = {Heidelberg},
   article_number = {6},
   doi = {https://doi.org/10.1007/s00429-014-0852-3},
   keywords = {Adolescents; Brain; Face; MRI; Prenatal androgens; Twins},
   language = {eng},
   issn = {1863-2653},
   journal = {Brain Structure and Function},
   title = {Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development},
   url = {http://link.springer.com/article/10.1007%2Fs00429-014-0852-3},
   volume = {220},
   year = {2015}
}

TY  - JOUR
ID  - 1209759
AU  - Marečková, Klára - Chakravarty, Mallar M. - Lawrence, Claire - Leonard, Gabriel - Perusse, Daniel - Perron, Michel - Pike, Bruce G. - Richer, Louis - Veillette, Suzanne - Pausová, Zdenka - Paus, Tomáš
PY  - 2015
TI  - Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development
JF  - Brain Structure and Function
VL  - 220
IS  - 6
SP  - 3233-3244
EP  - 3233-3244
PB  - Springer- Verlag Berlin Heidelberg
SN  - 18632653
KW  - Adolescents
KW  - Brain
KW  - Face
KW  - MRI
KW  - Prenatal androgens
KW  - Twins
UR  - http://link.springer.com/article/10.1007%2Fs00429-014-0852-3
L2  - http://link.springer.com/article/10.1007%2Fs00429-014-0852-3
N2  - We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d = 0.76). Subsequently, we tested the possibility that this craniofacial "signature" of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n = 462), we found that the facial signature predicts up to 8 % of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. © 2014 Springer-Verlag Berlin Heidelberg.
ER  -

MAREČKOVÁ, Klára; Mallar M. CHAKRAVARTY; Claire LAWRENCE; Gabriel LEONARD; Daniel PERUSSE; Michel PERRON; Bruce G. PIKE; Louis RICHER; Suzanne VEILLETTE; Zdenka PAUSOVÁ a Tomáš PAUS. Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. \textit{Brain Structure and Function}. Heidelberg: Springer- Verlag Berlin Heidelberg, 2015, roč.~220, č.~6, s.~3233-3244. ISSN~1863-2653. Dostupné z: https://doi.org/10.1007/s00429-014-0852-3.

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