| MAREČKOVÁ, Klára, Mallar M. CHAKRAVARTY, Claire LAWRENCE, Gabriel LEONARD, Daniel PERUSSE, Michel PERRON, Bruce G. PIKE, Louis RICHER, Suzanne VEILLETTE, Zdenka PAUSOVÁ and Tomáš PAUS. Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. Brain Structure and Function. Heidelberg: Springer- Verlag Berlin Heidelberg, 2015, vol. 220, No 6, p. 3233-3244. ISSN 1863-2653. Available from: https://dx.doi.org/10.1007/s00429-014-0852-3. |
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@article{1209759,
author = {Marečková, Klára and Chakravarty, Mallar M. and Lawrence, Claire and Leonard, Gabriel and Perusse, Daniel and Perron, Michel and Pike, Bruce G. and Richer, Louis and Veillette, Suzanne and Pausová, Zdenka and Paus, Tomáš},
article_location = {Heidelberg},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s00429-014-0852-3},
keywords = {Adolescents; Brain; Face; MRI; Prenatal androgens; Twins},
language = {eng},
issn = {1863-2653},
journal = {Brain Structure and Function},
title = {Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development},
url = {http://link.springer.com/article/10.1007%2Fs00429-014-0852-3},
volume = {220},
year = {2015}
}
TY - JOUR
ID - 1209759
AU - Marečková, Klára - Chakravarty, Mallar M. - Lawrence, Claire - Leonard, Gabriel - Perusse, Daniel - Perron, Michel - Pike, Bruce G. - Richer, Louis - Veillette, Suzanne - Pausová, Zdenka - Paus, Tomáš
PY - 2015
TI - Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development
JF - Brain Structure and Function
VL - 220
IS - 6
SP - 3233-3244
EP - 3233-3244
PB - Springer- Verlag Berlin Heidelberg
SN - 18632653
KW - Adolescents
KW - Brain
KW - Face
KW - MRI
KW - Prenatal androgens
KW - Twins
UR - http://link.springer.com/article/10.1007%2Fs00429-014-0852-3
L2 - http://link.springer.com/article/10.1007%2Fs00429-014-0852-3
N2 - We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d = 0.76). Subsequently, we tested the possibility that this craniofacial "signature" of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n = 462), we found that the facial signature predicts up to 8 % of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. © 2014 Springer-Verlag Berlin Heidelberg.
ER -
MAREČKOVÁ, Klára, Mallar M. CHAKRAVARTY, Claire LAWRENCE, Gabriel LEONARD, Daniel PERUSSE, Michel PERRON, Bruce G. PIKE, Louis RICHER, Suzanne VEILLETTE, Zdenka PAUSOVÁ and Tomáš PAUS. Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. \textit{Brain Structure and Function}. Heidelberg: Springer- Verlag Berlin Heidelberg, 2015, vol.~220, No~6, p.~3233-3244. ISSN~1863-2653. Available from: https://dx.doi.org/10.1007/s00429-014-0852-3.
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