Small-nerve-fiber pathology in critical illness documented by
serial skin biopsies

J 2015

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ et. al.

Basic information

Original name

Small-nerve-fiber pathology in critical illness documented by serial skin biopsies

Authors

ŠKORŇA, Miroslav (203 Czech Republic, guarantor, belonging to the institution), Roman KOPÁČIK (703 Slovakia, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Blanka ADAMOVÁ (203 Czech Republic, belonging to the institution), Milena KOŠŤÁLOVÁ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Muscle & nerve, New York, Wiley-Blackwell, 2015, 0148-639X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.713

RIV identification code

RIV/00216224:14110/15:00082172

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/mus.24489

UT WoS

000356498000005

Keywords in English

critical illness; small fibers; polyneuropathy; myopathy; skin biopsy

Abstract

V originále

Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MUNI/A/0935/2013, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti

Investor: Masaryk University, Category A

Files attached

EL_1209965.pdf

Request the author's version of the file

Citovat

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ and Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. Muscle & nerve. New York: Wiley-Blackwell, 2015, vol. 52, No 1, p. 28-33. ISSN 0148-639X. Available from: https://dx.doi.org/10.1002/mus.24489.

@article{1209965,
   author = {Škorňa, Miroslav and Kopáčik, Roman and Vlčková, Eva and Adamová, Blanka and Košťálová, Milena and Bednařík, Josef},
   article_location = {New York},
   article_number = {1},
   doi = {http://dx.doi.org/10.1002/mus.24489},
   keywords = {critical illness; small fibers; polyneuropathy; myopathy; skin biopsy},
   language = {eng},
   issn = {0148-639X},
   journal = {Muscle & nerve},
   note = {http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues},
   title = {Small-nerve-fiber pathology in critical illness documented by serial skin biopsies},
   volume = {52},
   year = {2015}
}

TY  - JOUR
ID  - 1209965
AU  - Škorňa, Miroslav - Kopáčik, Roman - Vlčková, Eva - Adamová, Blanka - Košťálová, Milena - Bednařík, Josef
PY  - 2015
TI  - Small-nerve-fiber pathology in critical illness documented by serial skin biopsies
JF  - Muscle & nerve
VL  - 52
IS  - 1
SP  - 28-33
EP  - 28-33
PB  - Wiley-Blackwell
SN  - 0148639X
N1  - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-4598/issues
KW  - critical illness
KW  - small fibers
KW  - polyneuropathy
KW  - myopathy
KW  - skin biopsy
N2  - Introduction: Small fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Methods: Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study. Intraepidermal never fiber density (IENFD) in the distal leg was assessed on admission to the intensive care unit and 10-14 days later, together with electrophysiological testing. Results: Of the 11 patients recruited, 9 (82%) had sepsis or multiple organ failure. Median IENFD on admission (5.05 fibers/mm) decreased significantly to 2.18 fibers/mm (P <0.001), and abnormal IENFD was found in 8 patients (72.7%). Electrodiagnostic signs of large fiber neuropathy and/or myopathy were found in 6 patients (54.5%), and autonomic dysfunction was found in 2 patients (18.2%). Discussion: Serial IENFD measurements confirmed the development of small fiber sensory involvement in the acute phase of critical illness.
ER  -

ŠKORŇA, Miroslav, Roman KOPÁČIK, Eva VLČKOVÁ, Blanka ADAMOVÁ, Milena KOŠŤÁLOVÁ and Josef BEDNAŘÍK. Small-nerve-fiber pathology in critical illness documented by serial skin biopsies. \textit{Muscle \&{} nerve}. New York: Wiley-Blackwell, 2015, vol.~52, No~1, p.~28-33. ISSN~0148-639X. Available from: https://dx.doi.org/10.1002/mus.24489.

Detailed Information on Publication Record