ŠEBERA, Jakub, Lukáš TRANTÍREK, Jiří FUKAL, Yoshiyuki TANAKA and Vladimír SYCHROVSKÝ. MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME. Chemické listy. Praha: Česká společnost chemická, 2014, vol. 108, No 4, p. 364-367. ISSN 0009-2770.
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Basic information
Original name MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME
Authors ŠEBERA, Jakub (203 Czech Republic), Lukáš TRANTÍREK (203 Czech Republic, guarantor, belonging to the institution), Jiří FUKAL (203 Czech Republic), Yoshiyuki TANAKA (392 Japan) and Vladimír SYCHROVSKÝ (203 Czech Republic).
Edition Chemické listy, Praha, Česká společnost chemická, 2014, 0009-2770.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.272
RIV identification code RIV/00216224:14740/14:00077390
Organization unit Central European Institute of Technology
UT WoS 000336833500012
Keywords in English NUCLEIC-ACID BASES; GLYCOSIDIC BOND-CLEAVAGE; HUMAN 8-OXOGUANINE GLYCOSYLASE; AB-INITIO; TRANSITION-STATE; PROTEIN HOGG1; HARTREE-FOCK; OGG1 GENE; RECOGNITION; GUANINE
Tags kontrola MP, MP, rivok
Tags International impact, Reviewed
Changed by Changed by: Martina Prášilová, učo 342282. Changed: 21/11/2014 10:39.
Abstract
This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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