MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME

ŠEBERA, Jakub, Lukáš TRANTÍREK, Jiří FUKAL, Yoshiyuki TANAKA and Vladimír SYCHROVSKÝ. MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME. Chemické listy. Praha: Česká společnost chemická, 2014, vol. 108, No 4, p. 364-367. ISSN 0009-2770.

Basic information

Original name

MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME

Authors

ŠEBERA, Jakub (203 Czech Republic), Lukáš TRANTÍREK (203 Czech Republic, guarantor, belonging to the institution), Jiří FUKAL (203 Czech Republic), Yoshiyuki TANAKA (392 Japan) and Vladimír SYCHROVSKÝ (203 Czech Republic)

Edition

Chemické listy, Praha, Česká společnost chemická, 2014, 0009-2770

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.272

RIV identification code

RIV/00216224:14740/14:00077390

Organization unit

Central European Institute of Technology

UT WoS

000336833500012

Keywords in English

NUCLEIC-ACID BASES; GLYCOSIDIC BOND-CLEAVAGE; HUMAN 8-OXOGUANINE GLYCOSYLASE; AB-INITIO; TRANSITION-STATE; PROTEIN HOGG1; HARTREE-FOCK; OGG1 GENE; RECOGNITION; GUANINE

Tags

kontrola MP, MP, rivok

Tags

International impact, Reviewed

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Abstract

V originále

This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

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Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology