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@article{1210675,
author = {Hel, Zdenek and Huijbregts, Richard P. H. and Xu, Jun and Nechvátalová, Jana and Vlková, Marcela and Litzman, Jiří},
article_location = {New York},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s10875-014-0099-z},
keywords = {Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation},
language = {eng},
issn = {0271-9142},
journal = {Journal of Clinical Immunology},
title = {Altered Serum Cytokine Signature in Common Variable Immunodeficiency},
volume = {34},
year = {2014}
}
TY - JOUR
ID - 1210675
AU - Hel, Zdenek - Huijbregts, Richard P. H. - Xu, Jun - Nechvátalová, Jana - Vlková, Marcela - Litzman, Jiří
PY - 2014
TI - Altered Serum Cytokine Signature in Common Variable Immunodeficiency
JF - Journal of Clinical Immunology
VL - 34
IS - 8
SP - 971-978
EP - 971-978
PB - Springer
SN - 02719142
KW - Common variable immunodeficiency
KW - IgA deficiency
KW - cytokine
KW - lymphocyte activation
N2 - Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. In contrast, the levels of cytokines typically produced by CD4+ T helper cells of Th1 (IFN-y, IL-2), Th2 (IL-9, IL-13), and Th17 (IL-17) subtypes were suppressed in CVID patients compared to healthy donors. Conclusions Presented data suggest that the altered cytokine profile observed in patients with CVID may be attributed to the activation of monocyte-macrophage and granulocyte lineages, possibly driven by the translocation of bacterial components across the gastrointestinal or respiratory tracts mucosal barrier.
ER -
HEL, Zdenek, Richard P. H. HUIJBREGTS, Jun XU, Jana NECHVÁTALOVÁ, Marcela VLKOVÁ a Jiří LITZMAN. Altered Serum Cytokine Signature in Common Variable Immunodeficiency. \textit{Journal of Clinical Immunology}. New York: Springer, 2014, roč.~34, č.~8, s.~971-978. ISSN~0271-9142. Dostupné z: https://dx.doi.org/10.1007/s10875-014-0099-z.
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