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@inbook{1211724,
author = {Šmajs, David and Strouhal, Michal},
address = {Amsterdam},
booktitle = {Molecular Medical Microbiology. Vol. 3},
doi = {http://dx.doi.org/10.1016/B978-0-12-397169-2.00079-2},
edition = {2nd ed.},
editor = {Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman},
keywords = {bejel; endemic treponematoses; pinta; syphilis; Treponema carateum; Treponema pallidum subsp. endemicum; T. pallidum subsp. pallidum; T. pallidum subsp. pertenue; T. paraluiscuniculi; yaws},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Amsterdam},
isbn = {978-0-12-397169-2},
pages = {1421-1436},
publisher = {Elsevier Science Ltd.},
title = {Uncultivable Pathogenic Treponemes},
year = {2015}
}
TY - CHAP
ID - 1211724
AU - Šmajs, David - Strouhal, Michal
PY - 2015
TI - Uncultivable Pathogenic Treponemes
VL - Neuveden
PB - Elsevier Science Ltd.
CY - Amsterdam
SN - 9780123971692
KW - bejel
KW - endemic treponematoses
KW - pinta
KW - syphilis
KW - Treponema carateum
KW - Treponema pallidum subsp. endemicum
KW - T. pallidum subsp. pallidum
KW - T. pallidum subsp. pertenue
KW - T. paraluiscuniculi
KW - yaws
N2 - Uncultivable pathogenic treponemes represent bacterial species and subspecies that are obligate pathogens of humans and animals. Treponema pallidum subsp. pallidum causes sexually transmitted syphilis, a multistage disease characterized in humans by localized, disseminated, and chronic forms of infection. Causative agents of endemic treponematoses comprise Treponema pallidum subsp. pertenue (agent of yaws), Treponema pallidum subsp. endemicum (agent of bejel) and T. carateum (agent of pinta) causing milder, non-venereal transmitted diseases affecting skin, bones and joints. Closely related treponemes, simian Treponema Fribourg-Blanc and T. paraluiscuniculi, cause infections in non-human primates and rabbits, respectively. T. paraluiscuniculi is not pathogenic to humans, whereas simian Treponema Fribourg-Blanc has been shown to cause experimental human infections. All human treponematoses share remarkable similarities in pathogenesis and clinical manifestations, consistent with the high genetic and antigenic relatedness of their aetiological agents. Pathogenic treponemes are characterized by low toxicity, high invasiveness, and high immuno-evasiveness. Moreover, treponemes are pathogens able to infect almost any type of human tissues, i.e. showing broad tissue tropism. All these pathogenic treponemes cannot be continuously cultivated under in vitro conditions. All uncultivable pathogenic treponemes have a reduced genome (~1.14 Mb) and represent clonal bacteria with identical genome structure having only minimal genetic differences in their genomic sequences.
ER -
ŠMAJS, David a Michal STROUHAL. Uncultivable Pathogenic Treponemes. In Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman. \textit{Molecular Medical Microbiology. Vol. 3}. 2nd ed. Amsterdam: Elsevier Science Ltd. s.~1421-1436. ISBN~978-0-12-397169-2. doi:10.1016/B978-0-12-397169-2.00079-2. 2015.
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