Long-term survival after alcohol septal ablation for
hypertrophic obstructive cardiomyopathy: a comparison with
general population

J 2014

Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population

VESELKA, Josef, Jan KREJČÍ, Pavol TOMAŠOV and David ZEMÁNEK

Basic information

Original name

Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population

Authors

VESELKA, Josef (203 Czech Republic), Jan KREJČÍ (203 Czech Republic, guarantor, belonging to the institution), Pavol TOMAŠOV (203 Czech Republic) and David ZEMÁNEK (203 Czech Republic)

Edition

European heart journal, Oxford, Oxford University Press, 2014, 0195-668X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 15.203

RIV identification code

RIV/00216224:14110/14:00077663

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/eurheartj/eht495

UT WoS

000342232400013

Keywords in English

Alcohol septal ablation; Prognosis; Hypertrophic cardiomyopathy

Abstract

V originále

Methods and results A total of 178 highly symptomatic, consecutive patients (58 +/- 12 years, 53% women) were treated by ASA between April 1998 and April 2013 and followed-up for 4.8 years (IQR 2.1-7.5). At baseline, 155 patients (87%) suffered from dyspnoea >= 3 class of NYHA; at the most recent examination, 87 patients (49%) and 23 patients (13%) reported dyspnoea of NYHA class 1 and >= 3, respectively. The left ventricular outflow gradient was significantly reduced (68 +/- 42 vs. 20 +/- 25 mmHg; P < 0.01). A total of 19 deaths (11%) occurred during 925 patient-years, which means an overall mortality rate of 2.1% per year. Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 93-99%), 92% (95% CI, 87-96%), and 82% (95% CI, 70-90%), respectively. This observed mortality was comparable to the expected survival for age- and sex-comparable general population (P = 0.34). According to multivariate analysis, the only independent predictor of all-cause mortality was age at ASA (hazard ratio 1.09, 95% CI 1.04-1.14; P < 0.01). Conclusions This study suggests that in patients with HOCM and important symptoms who underwent ASA, long-term survival after the procedure did not differ significantly from that of the general population.

Citovat

VESELKA, Josef, Jan KREJČÍ, Pavol TOMAŠOV and David ZEMÁNEK. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. European heart journal. Oxford: Oxford University Press, 2014, vol. 35, No 30, p. "2040"-"+", 7 pp. ISSN 0195-668X. Available from: https://dx.doi.org/10.1093/eurheartj/eht495.

@article{1211820,
   author = {Veselka, Josef and Krejčí, Jan and Tomašov, Pavol and Zemánek, David},
   article_location = {Oxford},
   article_number = {30},
   doi = {http://dx.doi.org/10.1093/eurheartj/eht495},
   keywords = {Alcohol septal ablation; Prognosis; Hypertrophic cardiomyopathy},
   language = {eng},
   issn = {0195-668X},
   journal = {European heart journal},
   title = {Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population},
   volume = {35},
   year = {2014}
}

TY  - JOUR
ID  - 1211820
AU  - Veselka, Josef - Krejčí, Jan - Tomašov, Pavol - Zemánek, David
PY  - 2014
TI  - Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population
JF  - European heart journal
VL  - 35
IS  - 30
SP  - "2040"-"+"
EP  - "2040"-"+"
PB  - Oxford University Press
SN  - 0195668X
KW  - Alcohol septal ablation
KW  - Prognosis
KW  - Hypertrophic cardiomyopathy
N2  - Methods and results A total of 178 highly symptomatic, consecutive patients (58 +/- 12 years, 53% women) were treated by ASA between April 1998 and April 2013 and followed-up for 4.8 years (IQR 2.1-7.5). At baseline, 155 patients (87%) suffered from dyspnoea >= 3 class of NYHA; at the most recent examination, 87 patients (49%) and 23 patients (13%) reported dyspnoea of NYHA class 1 and >= 3, respectively. The left ventricular outflow gradient was significantly reduced (68 +/- 42 vs. 20 +/- 25 mmHg; P < 0.01). A total of 19 deaths (11%) occurred during 925 patient-years, which means an overall mortality rate of 2.1% per year. Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 93-99%), 92% (95% CI, 87-96%), and 82% (95% CI, 70-90%), respectively. This observed mortality was comparable to the expected survival for age- and sex-comparable general population (P = 0.34). According to multivariate analysis, the only independent predictor of all-cause mortality was age at ASA (hazard ratio 1.09, 95% CI 1.04-1.14; P < 0.01). Conclusions This study suggests that in patients with HOCM and important symptoms who underwent ASA, long-term survival after the procedure did not differ significantly from that of the general population.
ER  -

VESELKA, Josef, Jan KREJČÍ, Pavol TOMAŠOV and David ZEMÁNEK. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. \textit{European heart journal}. Oxford: Oxford University Press, 2014, vol.~35, No~30, p.~''2040''-''+'', 7 pp. ISSN~0195-668X. Available from: https://dx.doi.org/10.1093/eurheartj/eht495.

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