OLEJNÍČKOVÁ, Kateřina, Veronika HOLÁ and Filip RŮŽIČKA. Catheter-related infections caused by Pseudomonas aeruginosa: Virulence factors involved and their relationships. Pathogens and Disease. Hoboken: Wiley-Blackwell, 2014, vol. 72, No 2, p. 87-94. ISSN 2049-632X. doi:10.1111/2049-632X.12188.
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Basic information
Original name Catheter-related infections caused by Pseudomonas aeruginosa: Virulence factors involved and their relationships
Authors OLEJNÍČKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Veronika HOLÁ (203 Czech Republic, guarantor, belonging to the institution) and Filip RŮŽIČKA (203 Czech Republic, belonging to the institution).
Edition Pathogens and Disease, Hoboken, Wiley-Blackwell, 2014, 2049-632X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.403
RIV identification code RIV/00216224:14110/14:00080153
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/2049-632X.12188
UT WoS 000345151900001
Keywords in English Antibiotic resistance; Biofilm; Blood stream; Pseudomonas aeruginosa; Urinary tract; Virulence factors
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 12. 1. 2015 15:19.
The nosocomial pathogen Pseudomonas aeruginosa is equipped with a large arsenal of cell-associated and secreted virulence factors which enhance its invasive potential. The complex relationships among virulence determinants have hitherto not been fully elucidated. In the present study, 175 catheter-related isolates were observed for the presence of selected virulence factors, namely extracellular enzymes and siderophore production, biofilm formation, resistance to antibiotics, and motility. A high percentage of the strains produced most of the tested virulence factors. A positive correlation was identified between the production of several exoproducts, and also between the formation of both types of biofilm. An opposite trend was observed between the two types of biofilm and the production of siderophores. Whereas the relationship between the submerged biofilm production (i.e. the biofilm formed on the solid surface below the water level) and the siderophore secretion was negative, the production of air-liquid interface (A-L) biofilm (i.e. the biofilm floating on the surface of the cultivation medium) and the siderophore secretion were positively correlated. All correlations were statistically significant at the level P = 0.05 with the correlation coefficient Y >= 0.50. Our results suggest that: (1) the co-production of the lytic enzymes and siderophores can play an important role in the pathogenesis of the catheter-related infections and should be taken into account when the virulence potential is assessed; (2) biofilm-positive strains are capable of forming both submerged and non-attached A-L biofilms; and (3) the different micro-environment in the submerged biofilm and A-L biofilm layers have opposite consequences for the production of other virulence factors.
NT13242, research and development projectName: Polymikrobiální biofilm jako příčina chronických močových infekcí a selhávání terapie: kultivační a PCR-DGGE diagnostika, význam a možnosti řešení
Investor: Ministry of Health of the CR
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