Prevalence and clinical significance of liver function
abnormalities in patients with acute heart failure

J 2015

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

VYSKOČILOVÁ, Klaudia, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Tereza MIKUŠOVÁ, Jiří VÍTOVEC et. al.

Basic information

Original name

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Authors

VYSKOČILOVÁ, Klaudia (703 Slovakia, guarantor, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Tereza MIKUŠOVÁ (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Josef MALEK (203 Czech Republic), Filip MALEK (203 Czech Republic), Ales LINHART (203 Czech Republic), Marian FEDORCO (203 Czech Republic), Petr WIDIMSKY (203 Czech Republic), Cestmir CIHALIK (203 Czech Republic), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution) and Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc, Palacký University, 2015, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.924

RIV identification code

RIV/00216224:14110/15:00082185

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2014.014

UT WoS

000364948100016

Keywords in English

heart failure; liver function tests; bilirubin; congestive hepatopathy; ischemic hepatitis

Abstract

V originále

Aims. Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF). Methods. The AHEAD (Acute Heart Failure Database) registry is a database conducted in 9 university hospitals and 5 regional health care facilities in the Czech Republic. From December 2004 to October 2012, the data of 8818 patients were included. The inclusion criteria for the database followed the European guidelines for AHF. Serum activities of all LFTs and total bilirubin were available in 1473 patients at the baseline. Results. In patients with AHF, abnormal LFTs were seen in 76% patients (total bilirubin in 34%, gama-glutamyltransferase in 44%, alkaline phosphatase in 20%, aspartate aminotransferase in 42%, alanine aminotransferase in 35%). Patients with cardiogenic shock were more likely to have LFTs abnormalities compared to mild AHF and pulmonary oedema. LFTs abnormalities were strongly associated with AHF severity (left ventricular ejection fraction and NYHA functional class) and clinical manifestation. While hepatocellular LFTs pattern predominated in left sided forward AHF, cholestatic profile occurred mainly in bilateral and right sided AHF. Additionally, patients with moderate to severe tricuspid regurgitation had significantly higher prevalence of abnormalities in cholestatic LFTs. Conclusions. Defining the LFTs profile typical for AHF plays an important role in management of AHF patients, since it may avoid redundant hepatic investigations and diagnostic misinterpretations.

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

NS9880, research and development project

Name: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model

Investor: Ministry of Health of the CR

Citovat

VYSKOČILOVÁ, Klaudia, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Tereza MIKUŠOVÁ, Jiří VÍTOVEC, Josef MALEK, Filip MALEK, Ales LINHART, Marian FEDORCO, Petr WIDIMSKY, Cestmir CIHALIK, Jiří PAŘENICA, Simona LITTNEROVÁ and Jiří JARKOVSKÝ. Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure. Biomedical Papers. Olomouc: Palacký University, 2015, vol. 159, No 3, p. 429-436. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2014.014.

@article{1212345,
   author = {Vyskočilová, Klaudia and Špinarová, Lenka and Špinar, Jindřich and Mikušová, Tereza and Vítovec, Jiří and Malek, Josef and Malek, Filip and Linhart, Ales and Fedorco, Marian and Widimsky, Petr and Cihalik, Cestmir and Pařenica, Jiří and Littnerová, Simona and Jarkovský, Jiří},
   article_location = {Olomouc},
   article_number = {3},
   doi = {http://dx.doi.org/10.5507/bp.2014.014},
   keywords = {heart failure; liver function tests; bilirubin; congestive hepatopathy; ischemic hepatitis},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   note = {http://biomed.papers.upol.cz/},
   title = {Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure},
   url = {http://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-0752#.VIWG_2NAT5E},
   volume = {159},
   year = {2015}
}

TY  - JOUR
ID  - 1212345
AU  - Vyskočilová, Klaudia - Špinarová, Lenka - Špinar, Jindřich - Mikušová, Tereza - Vítovec, Jiří - Malek, Josef - Malek, Filip - Linhart, Ales - Fedorco, Marian - Widimsky, Petr - Cihalik, Cestmir - Pařenica, Jiří - Littnerová, Simona - Jarkovský, Jiří
PY  - 2015
TI  - Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure
JF  - Biomedical Papers
VL  - 159
IS  - 3
SP  - 429-436
EP  - 429-436
PB  - Palacký University
SN  - 12138118
N1  - http://biomed.papers.upol.cz/
KW  - heart failure
KW  - liver function tests
KW  - bilirubin
KW  - congestive hepatopathy
KW  - ischemic hepatitis
UR  - http://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-0752#.VIWG_2NAT5E
N2  - Aims. Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF). Methods. The AHEAD (Acute Heart Failure Database) registry is a database conducted in 9 university hospitals and 5 regional health care facilities in the Czech Republic. From December 2004 to October 2012, the data of 8818 patients were included. The inclusion criteria for the database followed the European guidelines for AHF. Serum activities of all LFTs and total bilirubin were available in 1473 patients at the baseline. Results. In patients with AHF, abnormal LFTs were seen in 76% patients (total bilirubin in 34%, gama-glutamyltransferase in 44%, alkaline phosphatase in 20%, aspartate aminotransferase in 42%, alanine aminotransferase in 35%). Patients with cardiogenic shock were more likely to have LFTs abnormalities compared to mild AHF and pulmonary oedema. LFTs abnormalities were strongly associated with AHF severity (left ventricular ejection fraction and NYHA functional class) and clinical manifestation. While hepatocellular LFTs pattern predominated in left sided forward AHF, cholestatic profile occurred mainly in bilateral and right sided AHF. Additionally, patients with moderate to severe tricuspid regurgitation had significantly higher prevalence of abnormalities in cholestatic LFTs. Conclusions. Defining the LFTs profile typical for AHF plays an important role in management of AHF patients, since it may avoid redundant hepatic investigations and diagnostic misinterpretations.
ER  -

VYSKOČILOVÁ, Klaudia, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Tereza MIKUŠOVÁ, Jiří VÍTOVEC, Josef MALEK, Filip MALEK, Ales LINHART, Marian FEDORCO, Petr WIDIMSKY, Cestmir CIHALIK, Jiří PAŘENICA, Simona LITTNEROVÁ and Jiří JARKOVSKÝ. Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure. \textit{Biomedical Papers}. Olomouc: Palacký University, 2015, vol.~159, No~3, p.~429-436. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2014.014.

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