| RUZSÍKOVÁ, Adriána, Lenka SOUČKOVÁ, Pavel SUK, Radka OPATŘILOVÁ, Martina KEJDUŠOVÁ and Vladimír ŠRÁMEK. Quantitative analysis of drug losses administered via nasogastric tube - In vitro study. International Journal of Pharmaceutics. Amsterdam: Elsevier Science BV, 2015, vol. 478, No 1, p. 368-371. ISSN 0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2014.11.065. |
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@article{1212460,
author = {Ruzsíková, Adriána and Součková, Lenka and Suk, Pavel and Opatřilová, Radka and Kejdušová, Martina and Šrámek, Vladimír},
article_location = {Amsterdam},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.ijpharm.2014.11.065},
keywords = {Nasogastric tube; Intensive care; Dosage forms; Enteral feeding; Drug administration},
language = {eng},
issn = {0378-5173},
journal = {International Journal of Pharmaceutics},
title = {Quantitative analysis of drug losses administered via nasogastric tube - In vitro study},
url = {http://www.sciencedirect.com/science/article/pii/S0378517314008801},
volume = {478},
year = {2015}
}
TY - JOUR
ID - 1212460
AU - Ruzsíková, Adriána - Součková, Lenka - Suk, Pavel - Opatřilová, Radka - Kejdušová, Martina - Šrámek, Vladimír
PY - 2015
TI - Quantitative analysis of drug losses administered via nasogastric tube - In vitro study
JF - International Journal of Pharmaceutics
VL - 478
IS - 1
SP - 368-371
EP - 368-371
PB - Elsevier Science BV
SN - 03785173
KW - Nasogastric tube
KW - Intensive care
KW - Dosage forms
KW - Enteral feeding
KW - Drug administration
UR - http://www.sciencedirect.com/science/article/pii/S0378517314008801
N2 - Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A–E) and six dosage forms (simple compressed tablets – T/S; film coated tablets – T/FC; enteric coated tablets – T/EC; capsules with powder filling – C/P; capsules containing extended release pellets – C/ER; capsules containing gastro-resistant pellets – C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial losses associated with each step of drug administration were also determined. Results: Significant drug losses were measured (4–38%). Only methods A (crushing–beaker–syringe–water–NGT) and B (crushing–water–syringe–NGT) were suitable for administration of all tested dosage forms. Method B proved the most effective for all kinds of tablets and C/GR (p < 0.05) and tended to be more effective also for C/ER (p = 0.052) compared to method A. C/P showed minimal losses for both tested methods (B and E). Flushing of the drug through NGT causes major losses during drug administration compared to crushing and transfer (p < 0.05). All methods for intact pellets (C–E) were found inappropriate for clinical practice due to NGT clogging. Conclusions: Choosing a suitable administration method can significantly affect the amount of drugs delivered through NGT.
ER -
RUZSÍKOVÁ, Adriána, Lenka SOUČKOVÁ, Pavel SUK, Radka OPATŘILOVÁ, Martina KEJDUŠOVÁ and Vladimír ŠRÁMEK. Quantitative analysis of drug losses administered via nasogastric tube - In vitro study. \textit{International Journal of Pharmaceutics}. Amsterdam: Elsevier Science BV, 2015, vol.~478, No~1, p.~368-371. ISSN~0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2014.11.065.
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