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@article{1212507,
author = {Chrapek, Oldřich and Jarkovský, Jiří and Šín, Martin and Studnička, Jan and Kolář, Petr and Jirková, Barbora and Dušek, Ladislav and Pitrová, Šárka and Řehák, Jiří},
article_location = {New York},
article_number = {867479},
doi = {http://dx.doi.org/10.1155/2015/867479},
keywords = {ranibizumab; wet age-related macular degeneration; prognostic factor; early response},
language = {eng},
issn = {2090-004X},
journal = {Journal of Ophthalmology},
title = {Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration},
url = {http://www.hindawi.com/journals/joph/aa/867479/},
volume = {2015},
year = {2015}
}
TY - JOUR
ID - 1212507
AU - Chrapek, Oldřich - Jarkovský, Jiří - Šín, Martin - Studnička, Jan - Kolář, Petr - Jirková, Barbora - Dušek, Ladislav - Pitrová, Šárka - Řehák, Jiří
PY - 2015
TI - Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration
JF - Journal of Ophthalmology
VL - 2015
IS - 867479
SP - 1-4
EP - 1-4
PB - Hindawi
SN - 2090004X
KW - ranibizumab
KW - wet age-related macular degeneration
KW - prognostic factor
KW - early response
UR - http://www.hindawi.com/journals/joph/aa/867479/
N2 - Aim. To assess the significance of age, gender, baseline best corrected visual acuity, baseline macula thickness, and type and size of choroidal neovascularization in early morphological therapeutic response to ranibizumab treatment in patients with the wet form of age related macular degeneration. Methods. From 09/2008 to 06/2013 we evaluated 1153 newly diagnosed, treatment naive patients treated with ranibizumab. Based on the morphological findings in the macula following the initial 3 injections of ranibizumab, the patients were divided into two groups based on active and inactive choroidal neovascularization. Results. After the initial 3 injections of ranibizumab, we examined the sample of 841 eyes with active CNV and 312 eyes with inactive CNV. In the inactive group, we found a statistically higher proportion of occult CNV (P less than 0.001) and lower incidence of CNV greater than 5DA (P less than 0.001) compared with the active group. We found no statistically significant difference in age, gender, baseline best corrected visual acuity, or baseline macula thickness between the inactive and active groups. Conclusion. Occult CNV and CNV smaller than 5DA are optimistic factors for a better morphological therapeutic response at the beginning of ranibizumab treatment.
ER -
CHRAPEK, Oldřich, Jiří JARKOVSKÝ, Martin ŠÍN, Jan STUDNIČKA, Petr KOLÁŘ, Barbora JIRKOVÁ, Ladislav DUŠEK, Šárka PITROVÁ and Jiří ŘEHÁK. Prognostic Factors of Early Morphological Response to Treatment with Ranibizumab in Patients with Wet Age-Related Macular Degeneration. \textit{Journal of Ophthalmology}. New York: Hindawi, 2015, vol.~2015, No~867479, p.~1-4. ISSN~2090-004X. Available from: https://dx.doi.org/10.1155/2015/867479.
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