Doxorubicin and liposomal doxorubicin affect microRNA expression in rat right ventricles

NOVÁK, Jan, Tibor STRAČINA and Marie NOVÁKOVÁ. Doxorubicin and liposomal doxorubicin affect microRNA expression in rat right ventricles. In New Frontiers in Basic Cardiovascular Research 2014. 2014. ISBN 978-80-8141-064-2.

Basic information

Original name

Doxorubicin and liposomal doxorubicin affect microRNA expression in rat right ventricles

Authors

NOVÁK, Jan, Tibor STRAČINA and Marie NOVÁKOVÁ

Edition

New Frontiers in Basic Cardiovascular Research 2014, 2014

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Other information

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

ISBN

978-80-8141-064-2

Keywords in English

Doxorubicin; MicroRNA; Rat; Heart

Tags

International impact

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Abstract

V originále

In order to better understand the acute effects of doxorubicin (DOX) and liposomal DOX on the heart, analysis of 4 selected microRNAs (miR-208a/146a/216b/let-7g) that may be involved in DOX-induced cardiotoxicity was performed, both in the left and right ventricles of the Wistar rat exposed to one dose of DOX/liposomal DOX. This acute administration of mentioned drugs affects stightly expression of selected microRNAs, especially in right ventricle.

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Links

MUNI/A/0957/2013, interní kód MU

Name: Studium kardiovaskulárních regulací ve zdraví i nemoci (Acronym: SKAREZNEM) Investor: Masaryk University, Category A