Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK, Daniel Joel SHAW and Martin BAREŠ. Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients. Journal of Neural Transmission. Wien, Austria: Springer, 2014, vol. 121, No 12, p. 1507-1522. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-014-1221-3.

Basic information

• Original name: Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients
• Authors: MINKS, Eduard (203 Czech Republic, belonging to the institution), Pavel JURÁK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Josef HALÁMEK (203 Czech Republic), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, Wien, Austria, Springer, 2014, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.402
• RIV identification code: RIV/00216224:14110/14:00074222
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00702-014-1221-3
• UT WoS: 000345409000005
• Keywords in English: Intracranial electrodes; Mismatch negativity; MMN; MMN-like; STN; Subthalamic nucleus
• Tags: EL OK, podil
• Tags: International impact, Reviewed

Abstract

An infrequent change to an otherwise repetitive sequence of stimuli leads to the generation of mismatch negativity (MMN), even in the absence of attention. This evoked negative response occurs in the scalp-recorded electroencephalogram (EEG) over the temporal and frontal cortices, 100–250 ms after onset of the deviant stimulus. The MMN is used to detect sensory information processing. The aim of our study was to investigate whether MMN can be recorded in the subthalamic nuclei (STN) as evidence of auditory information processing on an unconscious level within this structure. To our knowledge, MMN has never been recorded in the human STN. We recorded intracerebral EEG using a MMN paradigm in five patients with Parkinson’s disease (PD) who were implanted with depth electrodes in the subthalamic nuclei (STN). We found far-field MMN when intracerebral contacts were connected to an extracranial reference electrode. In all five PD patients (and nine of ten intracerebral electrodes), we also found near-field MMN-like potentials when intracerebral contacts were referenced to one another, and in some electrodes, we observed phase reversals in these potentials. The mean time-to-peak latency of the intracerebral MMN-like potentials was 214 ± 38 ms (median 219 ms). We reveal MMN-like potentials in bilateral STN. This finding provides evidence that STN receives sensory (auditory) information from other structures. The question for further research is whether STN receives such signals through a previously described hyperdirect pathway between STN and frontal cortex (a known generator of the MMN potential) and if the STN contributes to sensorimotor integration.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP103/11/0933, research and development project: Name: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Investor: Czech Science Foundation

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.