J 2014

Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK et. al.

Basic information

Original name

Mismatch negativity-like potential (MMN-like) in the subthalamic nuclei in Parkinson’s disease patients

Authors

MINKS, Eduard (203 Czech Republic, belonging to the institution), Pavel JURÁK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Josef HALÁMEK (203 Czech Republic), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution) and Martin BAREŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neural Transmission, Wien, Austria, Springer, 2014, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.402

RIV identification code

RIV/00216224:14110/14:00074222

Organization unit

Faculty of Medicine

DOI

UT WoS

000345409000005

Keywords in English

Intracranial electrodes; Mismatch negativity; MMN; MMN-like; STN; Subthalamic nucleus

Tags

Tags

International impact, Reviewed
Změněno: 29/12/2014 11:38, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

An infrequent change to an otherwise repetitive sequence of stimuli leads to the generation of mismatch negativity (MMN), even in the absence of attention. This evoked negative response occurs in the scalp-recorded electroencephalogram (EEG) over the temporal and frontal cortices, 100–250 ms after onset of the deviant stimulus. The MMN is used to detect sensory information processing. The aim of our study was to investigate whether MMN can be recorded in the subthalamic nuclei (STN) as evidence of auditory information processing on an unconscious level within this structure. To our knowledge, MMN has never been recorded in the human STN. We recorded intracerebral EEG using a MMN paradigm in five patients with Parkinson’s disease (PD) who were implanted with depth electrodes in the subthalamic nuclei (STN). We found far-field MMN when intracerebral contacts were connected to an extracranial reference electrode. In all five PD patients (and nine of ten intracerebral electrodes), we also found near-field MMN-like potentials when intracerebral contacts were referenced to one another, and in some electrodes, we observed phase reversals in these potentials. The mean time-to-peak latency of the intracerebral MMN-like potentials was 214 ± 38 ms (median 219 ms). We reveal MMN-like potentials in bilateral STN. This finding provides evidence that STN receives sensory (auditory) information from other structures. The question for further research is whether STN receives such signals through a previously described hyperdirect pathway between STN and frontal cortex (a known generator of the MMN potential) and if the STN contributes to sensorimotor integration.

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology
GAP103/11/0933, research and development project
Name: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod
Investor: Czech Science Foundation
MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

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