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@proceedings{1214439,
author = {Dubská, Eva and Mrázková, Jana and Malinovská, Lenka and Adamová, Lenka and Demo, Gabriel and Pokorná, Martina and Wimmerová, Michaela},
booktitle = {2014 XVIII ISBC Conference, International Society for Biological Calorimetry},
keywords = {lectins isotermic titration calorimetry mutegenesis},
language = {eng},
title = {Studies of mutant lectin binding behaviour by microcalorimetry},
year = {2014}
}
TY - CONF
ID - 1214439
AU - Dubská, Eva - Mrázková, Jana - Malinovská, Lenka - Adamová, Lenka - Demo, Gabriel - Pokorná, Martina - Wimmerová, Michaela
PY - 2014
TI - Studies of mutant lectin binding behaviour by microcalorimetry
KW - lectins isotermic titration calorimetry mutegenesis
N2 - Bacterial lectins help pathogens in adhesion to sugar moieties presented on the host cell surface. Therefore, lectins from pathogenic bacteria and their adhesion modes are the subject of intense study. On the other hand, understanding of the basic principles of the lectin-carbohydrate binding process is still important task and can be helpful for further lectin engineering by targeted mutagenesis methods. Lectins with tuned affinity can offer interesting perspectives in biomedical or biotechnology. Our work is focused on the engineering of previously well studied lectins PA-IIL [1], CV-IIL [2], RS-IIL [3] and BC2L-A [4] from the PA-IIL lectin family. Effects of the mutations on the individual lectin binding behaviour were studied by isothermal titration microcalorimetry method (ITC).
ER -
DUBSKÁ, Eva, Jana MRÁZKOVÁ, Lenka MALINOVSKÁ, Lenka ADAMOVÁ, Gabriel DEMO, Martina POKORNÁ and Michaela WIMMEROVÁ. Studies of mutant lectin binding behaviour by microcalorimetry. In \textit{2014 XVIII ISBC Conference, International Society for Biological Calorimetry}. 2014.
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