Spinocelulárny karcinóm v ložisku cirkumskriptnej sklerodermie

ĎURČANSKÁ, Veronika, Hana JEDLIČKOVÁ, Ondřej SLÁMA, Lukáš VELECKÝ, Eva BŘEZINOVÁ and Vladimír VAŠKŮ. Spinocelulárny karcinóm v ložisku cirkumskriptnej sklerodermie (Squamous Cell Carcinoma in Localized Scleroderma). Klinická onkologie. Praha: Česká lékařská společnost J. E. Purkyně, 2014, vol. 27, No 6, p. 434-437. ISSN 0862-495X.

Basic information

Original name

Spinocelulárny karcinóm v ložisku cirkumskriptnej sklerodermie

Name (in English)

Squamous Cell Carcinoma in Localized Scleroderma

Authors

ĎURČANSKÁ, Veronika (703 Slovakia, guarantor, belonging to the institution), Hana JEDLIČKOVÁ (203 Czech Republic, belonging to the institution), Ondřej SLÁMA (203 Czech Republic, belonging to the institution), Lukáš VELECKÝ (203 Czech Republic, belonging to the institution), Eva BŘEZINOVÁ (203 Czech Republic, belonging to the institution) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Klinická onkologie, Praha, Česká lékařská společnost J. E. Purkyně, 2014, 0862-495X

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Other information

Language

Slovak

Type of outcome

Article in a journal

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

RIV identification code

RIV/00216224:14110/14:00077915

Organization unit

Faculty of Medicine

Keywords (in Czech)

lokalizovaná sklerodermia; spinocelulárny karcinóm; ulkus; osteomyelitída

Keywords in English

localized scleroderma; squamous cell carcinoma; ulcer; osteomyelitis

Tags

EL OK

Tags

Reviewed

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Abstract

V originále

Popisujeme případ mladej pacientky, u ktorej došlo k vzniku ulcerácií na právej nohe v teréne 15 rokov trvajúcej ložiskovgj sklerodermie (LS, morfey). Podlá CT vyšetrenia a RTG bol nález zhodnotený ako osteomyelitída a pacientka bola liečená kombináciou antibiotik. Opakované histologické vyšetrenia zo spodiny vředu preukázali granulačné tkanivo, chronické zápalové změny a pseudoepiteliomatóznu hyperpláziu. Stav ale progredoval a bolo nutné pristúpiť k amputécií pod kolenom. S odstupem troch mesiacov bola diagnostikovaná metastáza spino-celulárneho karcinomu v lymfatickej uzlině v triesle. Aj napriek kombinovanému přístupu (chirurgické] liečbe, rádioterapii a systémové chemoterapii) sa tvořili ďalšie metastázy a pacientka po niekolVých mesiacoch ochoreniu podlahla. Případ bol uzatvorený ako spinocelulárny karcinom maskovaný osteomyelitídou. Spinocelulárny karcinom v teréne ložiskové] sklerodermie je velVni vzácný a obvykle vzniká právě na dolných končatinách u pacientov s dlhotrvajúcou, pansklerotickou či generalizovanou morfeou.

In English

We present a case of a young 26-year-old woman, who has been suffering from localised scle-roderma (morphea) for 15 years. Recently, a lesion on the dorsum of her right foot ulcerated. Based on a CT scan and X-ray a diagnosis of ulcerative osteomyellitis was established. The patient was treated with a combination of antibiotics. Subsequent histological examinations showed granulomatous tissue and chronic inflammatory changes on top of pseudoepitelioma-tous hyperplasia. The patient's status was deteriorating, which resulted in a limb amputation under the knee. Three months later, there was a metastasis of squamous cell carcinoma found in the patient's inguinal lymph node. In spite of combined therapy (surgery, radioterapy and systemic chemotherapy), new metastases occurred and the patient succumbed to the disease several months afterwards. The case was concluded as a squamous cell carcinoma camouf¬laged by osteomyelitis. Malignant turn of localised sclerodema is very rare. It usually occurs on the lower extremities of patients with a long course of the disease and is associated with pansclerotic or generalised variants of morphea.