| VOJTÍŠEK, Radovan, Jan MUŽÍK, Pavel ŠLAMPA, Marie BUDÍKOVÁ, Jaroslav HEJSEK, Petr SMOLÁK, Jiří FERDA and Jindřich FÍNEK. The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer. Reports of Practical Oncology and Radiotherapy. Wroclaw: Elsevier Urban and Partner sp. z o.o., 2014, vol. 19, No 3, p. 182-190. ISSN 1507-1367. Available from: https://dx.doi.org/10.1016/j.rpor.2013.09.006. |
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@article{1214650,
author = {Vojtíšek, Radovan and Mužík, Jan and Šlampa, Pavel and Budíková, Marie and Hejsek, Jaroslav and Smolák, Petr and Ferda, Jiří and Fínek, Jindřich},
article_location = {Wroclaw},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.rpor.2013.09.006},
keywords = {Non-small cell lung cancer; NTCP; PET/CT; Radiotherapy planning; TCP},
language = {eng},
issn = {1507-1367},
journal = {Reports of Practical Oncology and Radiotherapy},
title = {The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer},
volume = {19},
year = {2014}
}
TY - JOUR
ID - 1214650
AU - Vojtíšek, Radovan - Mužík, Jan - Šlampa, Pavel - Budíková, Marie - Hejsek, Jaroslav - Smolák, Petr - Ferda, Jiří - Fínek, Jindřich
PY - 2014
TI - The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer
JF - Reports of Practical Oncology and Radiotherapy
VL - 19
IS - 3
SP - 182-190
EP - 182-190
PB - Elsevier Urban and Partner sp. z o.o.
SN - 15071367
KW - Non-small cell lung cancer
KW - NTCP
KW - PET/CT
KW - Radiotherapy planning
KW - TCP
N2 - Aim: To compare radiotherapy plans made according to CT and PET/CT and to investigate the impact of changes in target volumes on tumour control probability (TCP), normal tissue complication probability (NTCP) and the impact of PET/CT on the staging and treatment strategy. Background: Contemporary studies have proven that PET/CT attains higher sensitivity and specificity in the diagnosis of lung cancer and also leads to higher accuracy than CT alone in the process of target volume delineation in NSCLC. Materials and methods: Between October 2009 and March 2012, 31 patients with locally advanced NSCLC, who had been referred to radical radiotherapy were involved in our study. They all underwent planning PET/CT examination. Then we carried out two separate delineations of target volumes and two radiotherapy plans and we compared the following parameters of those plans: staging, treatment purpose, the size of GTV and PTV and the exposure of organs at risk (OAR). TCP and NTCP were also compared. Results: PET/CT information led to a significant decrease in the sizes of target volumes, which had the impact on the radiation exposure of OARs. The reduction of target volume sizes was not reflected in the significant increase of the TCP value. We found that there is a very strong direct linear relationship between all evaluated dosimetric parameters and NTCP values of all evaluated OARs. Conclusions: Our study found that the use of planning PET/CT in the radiotherapy planning of NSCLC has a crucial impact on the precise determination of target volumes, more precise staging of the disease and thus also on possible changes of treatment strategy.
ER -
VOJTÍŠEK, Radovan, Jan MUŽÍK, Pavel ŠLAMPA, Marie BUDÍKOVÁ, Jaroslav HEJSEK, Petr SMOLÁK, Jiří FERDA and Jindřich FÍNEK. The impact of PET/CT scanning on the size of target volumes, radiation exposure of organs at risk, TCP and NTCP, in the radiotherapy planning of non-small cell lung cancer. \textit{Reports of Practical Oncology and Radiotherapy}. Wroclaw: Elsevier Urban and Partner sp. z o.o., 2014, vol.~19, No~3, p.~182-190. ISSN~1507-1367. Available from: https://dx.doi.org/10.1016/j.rpor.2013.09.006.
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