Detailed Information on Publication Record
2015
The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.
REKTOR, Ivan, Martina BOČKOVÁ, Jan CHRASTINA, Irena REKTOROVÁ, Marek BALÁŽ et. al.Basic information
Original name
The modulatory role of subthalamic nucleus in cognitive functions - A viewpoint.
Authors
REKTOR, Ivan (203 Czech Republic, guarantor, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Marek BALÁŽ (703 Slovakia, belonging to the institution)
Edition
Clinical Neurophysiology, Clare (Ireland), Elsevier Ireland Ltd. 2015, 1388-2457
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.426
RIV identification code
RIV/00216224:14740/15:00082209
Organization unit
Central European Institute of Technology
UT WoS
000351092100004
Keywords in English
Cognitive functions; DBS; Electrophysiology; Non-motor functions; Subthalamic nucleus
Tags
International impact, Reviewed
Změněno: 25/2/2016 16:05, Martina Prášilová
Abstract
V originále
The modifications of electrophysiological activities of subthalamic nucleus (STN) by non-motor tasks, i.e. movement observation, emotional stimuli and impulse control, were reported repeatedly. Despite being a small structure, STN is apparently involved in a variety of functions. Based on our own electrophysiological recordings and results of other groups we believe that it acts as an indirect modulator which may be involved in tuning the functional systems. STN may modulate specific cognitive activities via contextual modulation of certain cortical areas. Our findings support the hypothesis of a cortical-STN bypass (via hyperdirect pathway) of "classical" basal ganglia-thalamocortical circuitry, at least during the processing of certain cognitive functions. The modulation of cognitive functions appears to be selective, probably determined by the involvement of cortical neuronal populations interconnected with STN. There could also exist a spatial overlap of areas within STN regulating various functions. That may explain the fact that some non-motor symptoms of Parkinson's disease may improve after deep brain stimulation of STN. These improvements are likely caused by combination of direct stimulation effect on non-motor function and overall beneficial effect of motor improvement on quality of life.
Links
| ED1.1.00/02.0068, research and development project |
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