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@proceedings{1215603,
author = {Langmajerová, Monika and Michalcová, Lenka and Glatz, Zdeněk},
booktitle = {Annual Conference Brno 2014: Frontiers in Material and Life Sciences},
keywords = {capillary electrophoresis, mass spectrometry, interaction, drug - HSA},
isbn = {978-80-210-7159-9},
title = {Application of capillary electrophoresis hyphenated to mass spectrometry to protein – drug interaction study.},
url = {http://www.ceitec.eu/ceitec-annual-conference/},
year = {2014}
}
TY - CONF
ID - 1215603
AU - Langmajerová, Monika - Michalcová, Lenka - Glatz, Zdeněk
PY - 2014
TI - Application of capillary electrophoresis hyphenated to mass spectrometry to protein – drug interaction study.
SN - 9788021071599
KW - capillary electrophoresis, mass spectrometry, interaction, drug - HSA
UR - http://www.ceitec.eu/ceitec-annual-conference/
N2 - In this study binding constants for interaction between anti-diabetic agent glimepiride and human serum albumin were determined by capillary electrophoresis mass spectrometry in frontal analysis mode. This approach provides analyses under near-physiological condition and it is well suited for measurement of binding constant. Glimepiride is poorly soluble drug and belongs to third generation sulfonylurea used for treatment of diabetes mellitus type 2.
ER -
LANGMAJEROVÁ, Monika, Lenka MICHALCOVÁ and Zdeněk GLATZ. Application of capillary electrophoresis hyphenated to mass spectrometry to protein – drug interaction study. In \textit{Annual Conference Brno 2014: Frontiers in Material and Life Sciences}. 2014. ISBN~978-80-210-7159-9.
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