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@proceedings{1215604,
author = {Langmajerová, Monika and Řemínek, Roman and Glatz, Zdeněk},
booktitle = {EBF 7th Open Meeting: "Beyond the Horizon - Painting a New Landscape" 2014.},
keywords = {capillary electrophoresis, mass spectrometry, online reaction, cytochromes P450},
title = {Online incubation of cytochrome P450 and drugs employing capillary electrophoresis coupled with mass spectrometry},
url = {http://bcn2014.europeanbioanalysisforum.eu/General/},
year = {2014}
}
TY - CONF
ID - 1215604
AU - Langmajerová, Monika - Řemínek, Roman - Glatz, Zdeněk
PY - 2014
TI - Online incubation of cytochrome P450 and drugs employing capillary electrophoresis coupled with mass spectrometry
KW - capillary electrophoresis, mass spectrometry, online reaction, cytochromes P450
UR - http://bcn2014.europeanbioanalysisforum.eu/General/
N2 - Capillary electrophoresis (CE) combined with quadrupole - time of flight mass spectrometer (QTOF-MS) represents a universal tool for microscale enzyme assay, because capillary can be used not only as separation tool but also as reaction chamber. Method for reaction mixture mixing based on diffusion provides mixture with uniform concentration of reactants. In this contribution on-line CE-QTOF-MS method for study of diclofenac metabolism mediated by cytochrome P450 2C9 isoenzyme or human liver microsomes is presented. Michaelis constants were determined.
ER -
LANGMAJEROVÁ, Monika, Roman ŘEMÍNEK a Zdeněk GLATZ. Online incubation of cytochrome P450 and drugs employing capillary electrophoresis coupled with mass spectrometry. In \textit{EBF 7th Open Meeting: ''Beyond the Horizon - Painting a New Landscape'' 2014.}. 2014.
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