ŠPLÍCHAL, Zbyněk, Julie BIENERTOVÁ VAŠKŮ, Jan NOVÁK, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Martin FOREJT, Soňa HAVLENOVÁ, Aneta JACKOWSKÁ and Anna VAŠKŮ. The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population. Nutritional Neuroscience. West Yorkshire: Maney Publishing, 2015, vol. 18, No 1, p. 41-48. ISSN 1028-415X. doi:10.1179/1476830513Y.0000000100.
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Basic information
Original name The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population
Authors ŠPLÍCHAL, Zbyněk (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Soňa HAVLENOVÁ (203 Czech Republic, belonging to the institution), Aneta JACKOWSKÁ (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Nutritional Neuroscience, West Yorkshire, Maney Publishing, 2015, 1028-415X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.616
RIV identification code RIV/00216224:14110/15:00082224
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1179/1476830513Y.0000000100
UT WoS 000346538800006
Keywords in English Adipose tissue; Energy intake; Fat intake; Omentin; Val109Asp polymorphism
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 9/7/2015 10:21.
Abstract
Background: Omentin is an adipokine expressed predominantly in visceral adipose tissue, with adipose tissue stromal cells being the main source. Very little is known about the relationship between the genetic variability of the omentin gene and pathophysiology of obesity, although omentin is believed to play an important role in visceral obesity development. The aim of the study was to investigate two common polymorphisms in the omentin gene (rs2274908 and rs2274907) and dietary composition and anthropometric parameters of obesity in the Central European population. Material and methods: A total of 495 subjects were included into the study, they were further dividend into the non-obese, obese, and morbidly obese cohorts. Dietary habits were established using the 7-day food records and selected anthropometric parameters were measured. Results: There were significant differences in genotype distributions of rs2274907 between the obese and morbidly obese cohorts (P = 0.01). In the multivariate modelling, the rs2274907 polymorphism expressed independent prediction role for the daily energy intake, independently on the age and gender (P = 0.03); the TT genotype associated with the lowest (7877 ± 2780 J/day) and the AA genotype with the highest (8764 ± 2467 J/day) average energy intake. The rs2274907 also significantly associated with the daily consumption of fat and proteins. Conclusion: This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.
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