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@article{1216467,
author = {Baliakas, Panagiotis and Iskas, Michail and Gardiner, Anne and Davis, Zadie and Plevová, Karla and Florence, NguyenandKhac and Malčíková, Jitka and Anagnostopoulos, Achlles and Glide, Sharron and Mould, Sarah and Štěpanovská, Kristina and Brejcha, Martin and Belessi, Chrysoula and Davi, Frederic and Pospíšilová, Šárka and Athanasiadou, Anastasia and Stamatopoulos, Kostas and Oscier, David},
article_location = {Hoboken},
article_number = {3},
doi = {http://dx.doi.org/10.1002/ajh.23618},
keywords = {INDUCED CYTIDINE DEAMINASE; SEQUENCING REVEALS; TP53 MUTATION; PROGNOSTIC SUBGROUPS; GENOMIC ABERRATIONS; NOTCH1 MUTATIONS; POOR-PROGNOSIS; NORMAL FISH; B-CELLS; CLL},
language = {eng},
issn = {0361-8609},
journal = {American Journal of Hematology},
title = {Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data},
url = {http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03},
volume = {89},
year = {2014}
}
TY - JOUR
ID - 1216467
AU - Baliakas, Panagiotis - Iskas, Michail - Gardiner, Anne - Davis, Zadie - Plevová, Karla - Florence, Nguyen-Khac - Malčíková, Jitka - Anagnostopoulos, Achlles - Glide, Sharron - Mould, Sarah - Štěpanovská, Kristina - Brejcha, Martin - Belessi, Chrysoula - Davi, Frederic - Pospíšilová, Šárka - Athanasiadou, Anastasia - Stamatopoulos, Kostas - Oscier, David
PY - 2014
TI - Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data
JF - American Journal of Hematology
VL - 89
IS - 3
SP - 249-255
EP - 249-255
PB - Wiley-Blackwell
SN - 03618609
KW - INDUCED CYTIDINE DEAMINASE
KW - SEQUENCING REVEALS
KW - TP53 MUTATION
KW - PROGNOSTIC SUBGROUPS
KW - GENOMIC ABERRATIONS
KW - NOTCH1 MUTATIONS
KW - POOR-PROGNOSIS
KW - NORMAL FISH
KW - B-CELLS
KW - CLL
UR - http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03
L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03
N2 - The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (3 aberrations) was detected in 157 cases and significantly (P<0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time-to-first-treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior. Am. J. Hematol. 89:249-255, 2014. (c) 2013 Wiley Periodicals, Inc.
ER -
BALIAKAS, Panagiotis, Michail ISKAS, Anne GARDINER, Zadie DAVIS, Karla PLEVOVÁ, Nguyen-Khac FLORENCE, Jitka MALČÍKOVÁ, Achlles ANAGNOSTOPOULOS, Sharron GLIDE, Sarah MOULD, Kristina ŠTĚPANOVSKÁ, Martin BREJCHA, Chrysoula BELESSI, Frederic DAVI, Šárka POSPÍŠILOVÁ, Anastasia ATHANASIADOU, Kostas STAMATOPOULOS and David OSCIER. Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data. \textit{American Journal of Hematology}. Hoboken: Wiley-Blackwell, vol.~89, No~3, p.~249-255. ISSN~0361-8609. doi:10.1002/ajh.23618. 2014.
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