Chromosomal translocations and karyotype complexity in chronic
lymphocytic leukemia: A systematic reappraisal of classic
cytogenetic data

J 2014

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

BALIAKAS, Panagiotis, Michail ISKAS, Anne GARDINER, Zadie DAVIS, Karla PLEVOVÁ et. al.

Basic information

Original name

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Authors

BALIAKAS, Panagiotis (300 Greece), Michail ISKAS (300 Greece), Anne GARDINER (826 United Kingdom of Great Britain and Northern Ireland), Zadie DAVIS (826 United Kingdom of Great Britain and Northern Ireland), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Nguyen-Khac FLORENCE (250 France), Jitka MALČÍKOVÁ (203 Czech Republic, belonging to the institution), Achlles ANAGNOSTOPOULOS (300 Greece), Sharron GLIDE (826 United Kingdom of Great Britain and Northern Ireland), Sarah MOULD (826 United Kingdom of Great Britain and Northern Ireland), Kristina ŠTĚPANOVSKÁ (203 Czech Republic, belonging to the institution), Martin BREJCHA (203 Czech Republic), Chrysoula BELESSI (300 Greece), Frederic DAVI (250 France), Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution), Anastasia ATHANASIADOU (300 Greece), Kostas STAMATOPOULOS (300 Greece) and David OSCIER (826 United Kingdom of Great Britain and Northern Ireland)

Edition

American Journal of Hematology, Hoboken, Wiley-Blackwell, 2014, 0361-8609

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.798

RIV identification code

RIV/00216224:14740/14:00078303

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/ajh.23618

UT WoS

000331941600003

Keywords in English

INDUCED CYTIDINE DEAMINASE; SEQUENCING REVEALS; TP53 MUTATION; PROGNOSTIC SUBGROUPS; GENOMIC ABERRATIONS; NOTCH1 MUTATIONS; POOR-PROGNOSIS; NORMAL FISH; B-CELLS; CLL

Abstract

V originále

The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (3 aberrations) was detected in 157 cases and significantly (P<0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time-to-first-treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior. Am. J. Hematol. 89:249-255, 2014. (c) 2013 Wiley Periodicals, Inc.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

EE2.3.20.0045, research and development project

Name: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

NT13493, research and development project

Name: Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie

Citovat

BALIAKAS, Panagiotis, Michail ISKAS, Anne GARDINER, Zadie DAVIS, Karla PLEVOVÁ, Nguyen-Khac FLORENCE, Jitka MALČÍKOVÁ, Achlles ANAGNOSTOPOULOS, Sharron GLIDE, Sarah MOULD, Kristina ŠTĚPANOVSKÁ, Martin BREJCHA, Chrysoula BELESSI, Frederic DAVI, Šárka POSPÍŠILOVÁ, Anastasia ATHANASIADOU, Kostas STAMATOPOULOS and David OSCIER. Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data. American Journal of Hematology. Hoboken: Wiley-Blackwell, 2014, vol. 89, No 3, p. 249-255. ISSN 0361-8609. Available from: https://dx.doi.org/10.1002/ajh.23618.

@article{1216467,
   author = {Baliakas, Panagiotis and Iskas, Michail and Gardiner, Anne and Davis, Zadie and Plevová, Karla and Florence, NguyenandKhac and Malčíková, Jitka and Anagnostopoulos, Achlles and Glide, Sharron and Mould, Sarah and Štěpanovská, Kristina and Brejcha, Martin and Belessi, Chrysoula and Davi, Frederic and Pospíšilová, Šárka and Athanasiadou, Anastasia and Stamatopoulos, Kostas and Oscier, David},
   article_location = {Hoboken},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/ajh.23618},
   keywords = {INDUCED CYTIDINE DEAMINASE; SEQUENCING REVEALS; TP53 MUTATION; PROGNOSTIC SUBGROUPS; GENOMIC ABERRATIONS; NOTCH1 MUTATIONS; POOR-PROGNOSIS; NORMAL FISH; B-CELLS; CLL},
   language = {eng},
   issn = {0361-8609},
   journal = {American Journal of Hematology},
   title = {Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03},
   volume = {89},
   year = {2014}
}

TY  - JOUR
ID  - 1216467
AU  - Baliakas, Panagiotis - Iskas, Michail - Gardiner, Anne - Davis, Zadie - Plevová, Karla - Florence, Nguyen-Khac - Malčíková, Jitka - Anagnostopoulos, Achlles - Glide, Sharron - Mould, Sarah - Štěpanovská, Kristina - Brejcha, Martin - Belessi, Chrysoula - Davi, Frederic - Pospíšilová, Šárka - Athanasiadou, Anastasia - Stamatopoulos, Kostas - Oscier, David
PY  - 2014
TI  - Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data
JF  - American Journal of Hematology
VL  - 89
IS  - 3
SP  - 249-255
EP  - 249-255
PB  - Wiley-Blackwell
SN  - 03618609
KW  - INDUCED CYTIDINE DEAMINASE
KW  - SEQUENCING REVEALS
KW  - TP53 MUTATION
KW  - PROGNOSTIC SUBGROUPS
KW  - GENOMIC ABERRATIONS
KW  - NOTCH1 MUTATIONS
KW  - POOR-PROGNOSIS
KW  - NORMAL FISH
KW  - B-CELLS
KW  - CLL
UR  - http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03
L2  - http://onlinelibrary.wiley.com/doi/10.1002/ajh.23618/abstract;jsessionid=DAD660CE5456CF4FDBCEF4836A1B4356.f01t03
N2  - The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (3 aberrations) was detected in 157 cases and significantly (P<0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time-to-first-treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior. Am. J. Hematol. 89:249-255, 2014. (c) 2013 Wiley Periodicals, Inc.
ER  -

BALIAKAS, Panagiotis, Michail ISKAS, Anne GARDINER, Zadie DAVIS, Karla PLEVOVÁ, Nguyen-Khac FLORENCE, Jitka MALČÍKOVÁ, Achlles ANAGNOSTOPOULOS, Sharron GLIDE, Sarah MOULD, Kristina ŠTĚPANOVSKÁ, Martin BREJCHA, Chrysoula BELESSI, Frederic DAVI, Šárka POSPÍŠILOVÁ, Anastasia ATHANASIADOU, Kostas STAMATOPOULOS and David OSCIER. Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data. \textit{American Journal of Hematology}. Hoboken: Wiley-Blackwell, 2014, vol.~89, No~3, p.~249-255. ISSN~0361-8609. Available from: https://dx.doi.org/10.1002/ajh.23618.

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