MALČÍKOVÁ, Jitka, Evangelia STALIKA, Zadie DAVIS, Karla PLEVOVÁ, Martin TRBUŠEK, Larry MANSOURI, Lydia SCARFO, Panagiotis BALIAKAS, Anne GARDINER, LA SUTTON, Hana Skuhrová FRANCOVA, Andreas AGATHANGELIDIS, Achilles ANAGNOSTOPOULOS, Ian TRACY, Antonis MAKRIS, Jana ŠMARDOVÁ, Paolo GHIA, Chrysoula BELESSI, David GONZALEZ, Richard ROSENQUIST, David OSCIER, Šárka POSPÍŠILOVÁ and Kostas STAMATOPOULOS. The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors. British Journal of Haematology. Hoboken (USA): Wiley-Blackwell, 2014, vol. 166, No 4, p. 621-625. ISSN 0007-1048. doi:10.1111/bjh.12893.
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Basic information
Original name The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors
Authors MALČÍKOVÁ, Jitka (203 Czech Republic, belonging to the institution), Evangelia STALIKA (300 Greece), Zadie DAVIS (826 United Kingdom of Great Britain and Northern Ireland), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Martin TRBUŠEK (203 Czech Republic, belonging to the institution), Larry MANSOURI (752 Sweden), Lydia SCARFO (380 Italy), Panagiotis BALIAKAS (300 Greece), Anne GARDINER (826 United Kingdom of Great Britain and Northern Ireland), LA SUTTON (752 Sweden), Hana Skuhrová FRANCOVA (203 Czech Republic), Andreas AGATHANGELIDIS (380 Italy), Achilles ANAGNOSTOPOULOS (300 Greece), Ian TRACY (826 United Kingdom of Great Britain and Northern Ireland), Antonis MAKRIS (300 Greece), Jana ŠMARDOVÁ (203 Czech Republic), Paolo GHIA (380 Italy), Chrysoula BELESSI (300 Greece), David GONZALEZ (826 United Kingdom of Great Britain and Northern Ireland), Richard ROSENQUIST (752 Sweden), David OSCIER (826 United Kingdom of Great Britain and Northern Ireland), Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Kostas STAMATOPOULOS (300 Greece).
Edition British Journal of Haematology, Hoboken (USA), Wiley-Blackwell, 2014, 0007-1048.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.971
RIV identification code RIV/00216224:14740/14:00078324
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1111/bjh.12893
UT WoS 000340237900022
Keywords in English chronic lymphocytic leukaemia; immunoglobulin genes; stereotyped B cell receptors; TP53 mutations; prognosis
Tags EL OK, kontrola MP, ok, podil, podíl ceitec, rivok
Tags International impact, Reviewed
Changed by Changed by: Martina Prášilová, učo 342282. Changed: 28. 4. 2015 13:09.
Abstract
In chronic lymphocytic leukaemia (CLL) tumour initiation and progression are linked to the interplay between cellextrinsic and cell-intrinsic mechanisms. Cell-extrinsic mechanisms relate to the crosstalk of CLL cells with their microenvironment through various receptors, including the B-cell receptor (BcR).
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
EE2.3.20.0045, research and development projectName: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny
NT13493, research and development projectName: Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie
NT13519, research and development projectName: Časná identifikace CLL pacientů s dosud nevyselektovanými mutacemi v proteinu p53
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