Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ and Michal MIKL. Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, 2014, vol. 42, No 3, p. "S217"-"S228", 12 pp. ISSN 1387-2877. Available from: https://dx.doi.org/10.3233/JAD-132684.

Basic information

• Original name: Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease
• Authors: REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Lenka KRAJČOVIČOVÁ (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution).
• Edition: JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2014, 1387-2877.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.151
• RIV identification code: RIV/00216224:14740/14:00074324
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.3233/JAD-132684
• UT WoS: 000341595800023
• Keywords in English: Default mode network; dementia; functional MRI; Parkinson's disease; precuneus; visual processing
• Tags: kontrola MP, MP, rivok
• Tags: International impact, Reviewed

Abstract

Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set at p(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negative. Both PD and PDD showed disturbed DMN connectivity with the brain regions that are involved in bottom-up visual processing. In PD, we also found impaired integration of the areas engaged in the ventral attentional network, which might reflect specific attentional deficits observed during the early course of PD. In mild PDD, we detected increased engagement of areas involved in the dorsal attentional network, which corresponds to increased top-down control in this patient group as compared to the healthy controls. Conclusion: Our results show impaired dynamic interplay between large scale brain networks in PD that spread far beyond the motor system.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP103/12/0552, research and development project: Name: Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI

Investor: Czech Science Foundation

• NT13499, research and development project: Name: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci