J 2014

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ, Michal MIKL et. al.

Basic information

Original name

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Authors

REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Lenka KRAJČOVIČOVÁ (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2014, 1387-2877

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.151

RIV identification code

RIV/00216224:14740/14:00074324

Organization unit

Central European Institute of Technology

DOI

UT WoS

000341595800023

Keywords in English

Default mode network; dementia; functional MRI; Parkinson's disease; precuneus; visual processing

Tags

Tags

International impact, Reviewed
Změněno: 12/3/2015 07:01, Martina Prášilová

Abstract

V originále

Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set at p(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negative. Both PD and PDD showed disturbed DMN connectivity with the brain regions that are involved in bottom-up visual processing. In PD, we also found impaired integration of the areas engaged in the ventral attentional network, which might reflect specific attentional deficits observed during the early course of PD. In mild PDD, we detected increased engagement of areas involved in the dorsal attentional network, which corresponds to increased top-down control in this patient group as compared to the healthy controls. Conclusion: Our results show impaired dynamic interplay between large scale brain networks in PD that spread far beyond the motor system.

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology
GAP103/12/0552, research and development project
Name: Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI
Investor: Czech Science Foundation
NT13499, research and development project
Name: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci