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@article{1216644,
author = {Rektorová, Irena and Krajčovičová, Lenka and Mareček, Radek and Nováková, Marie and Mikl, Michal},
article_location = {AMSTERDAM},
article_number = {3},
doi = {http://dx.doi.org/10.3233/JAD-132684},
keywords = {Default mode network; dementia; functional MRI; Parkinson's disease; precuneus; visual processing},
language = {eng},
issn = {1387-2877},
journal = {JOURNAL OF ALZHEIMERS DISEASE},
title = {Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease},
url = {https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf},
volume = {42},
year = {2014}
}
TY - JOUR
ID - 1216644
AU - Rektorová, Irena - Krajčovičová, Lenka - Mareček, Radek - Nováková, Marie - Mikl, Michal
PY - 2014
TI - Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease
JF - JOURNAL OF ALZHEIMERS DISEASE
VL - 42
IS - 3
SP - "S217"-"S228"
EP - "S217"-"S228"
PB - IOS PRESS
SN - 13872877
KW - Default mode network
KW - dementia
KW - functional MRI
KW - Parkinson's disease
KW - precuneus
KW - visual processing
UR - https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf
L2 - https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf
N2 - Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set at p(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negative. Both PD and PDD showed disturbed DMN connectivity with the brain regions that are involved in bottom-up visual processing. In PD, we also found impaired integration of the areas engaged in the ventral attentional network, which might reflect specific attentional deficits observed during the early course of PD. In mild PDD, we detected increased engagement of areas involved in the dorsal attentional network, which corresponds to increased top-down control in this patient group as compared to the healthy controls. Conclusion: Our results show impaired dynamic interplay between large scale brain networks in PD that spread far beyond the motor system.
ER -
REKTOROVÁ, Irena, Lenka KRAJČOVIČOVÁ, Radek MAREČEK, Marie NOVÁKOVÁ a Michal MIKL. Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2014, roč.~42, č.~3, s.~''S217''-''S228'', 12 s. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-132684.
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