| KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL and Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. NEW YORK: SPRINGER, 2014, vol. 14, No 10, p. "nestránkované", 7 pp. ISSN 1528-4042. Available from: https://dx.doi.org/10.1007/s11910-014-0491-3. |
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@article{1216651,
author = {Krajčovičová, Lenka and Mareček, Radek and Mikl, Michal and Rektorová, Irena},
article_location = {NEW YORK},
article_number = {10},
doi = {http://dx.doi.org/10.1007/s11910-014-0491-3},
keywords = {Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment},
language = {eng},
issn = {1528-4042},
journal = {CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS},
title = {Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects},
url = {http://link.springer.com/article/10.1007%2Fs11910-014-0491-3},
volume = {14},
year = {2014}
}
TY - JOUR
ID - 1216651
AU - Krajčovičová, Lenka - Mareček, Radek - Mikl, Michal - Rektorová, Irena
PY - 2014
TI - Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects
JF - CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
VL - 14
IS - 10
SP - "nestránkované"
EP - "nestránkované"
PB - SPRINGER
SN - 15284042
KW - Functional connectivity
KW - fMRI
KW - Resting state
KW - Resting state networks
KW - Default mode network
KW - Alzheimer's disease
KW - Mild cognitive impairment
UR - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
L2 - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
N2 - The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.
ER -
KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL and Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. \textit{CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS}. NEW YORK: SPRINGER, 2014, vol.~14, No~10, p.~''nestránkované'', 7 pp. ISSN~1528-4042. Available from: https://dx.doi.org/10.1007/s11910-014-0491-3.
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