Disruption of Resting Functional Connectivity in Alzheimer's
Patients and At-Risk Subjects

J 2014

Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL and Irena REKTOROVÁ

Basic information

Original name

Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects

Authors

KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, NEW YORK, SPRINGER, 2014, 1528-4042

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.059

RIV identification code

RIV/00216224:14740/14:00074325

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s11910-014-0491-3

UT WoS

000342073900008

Keywords in English

Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment

Abstract

V originále

The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GA14-33143S, research and development project

Name: Vliv fyziologických procesů na reliabilitu a časovou proměnlivost konektivity v lidském mozku měřené pomocí fMRI

Investor: Czech Science Foundation

Citovat

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL and Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. NEW YORK: SPRINGER, 2014, vol. 14, No 10, p. "nestránkované", 7 pp. ISSN 1528-4042. Available from: https://dx.doi.org/10.1007/s11910-014-0491-3.

@article{1216651,
   author = {Krajčovičová, Lenka and Mareček, Radek and Mikl, Michal and Rektorová, Irena},
   article_location = {NEW YORK},
   article_number = {10},
   doi = {http://dx.doi.org/10.1007/s11910-014-0491-3},
   keywords = {Functional connectivity; fMRI; Resting state; Resting state networks; Default mode network; Alzheimer's disease; Mild cognitive impairment},
   language = {eng},
   issn = {1528-4042},
   journal = {CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS},
   title = {Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects},
   url = {http://link.springer.com/article/10.1007%2Fs11910-014-0491-3},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1216651
AU  - Krajčovičová, Lenka - Mareček, Radek - Mikl, Michal - Rektorová, Irena
PY  - 2014
TI  - Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects
JF  - CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
VL  - 14
IS  - 10
SP  - "nestránkované"
EP  - "nestránkované"
PB  - SPRINGER
SN  - 15284042
KW  - Functional connectivity
KW  - fMRI
KW  - Resting state
KW  - Resting state networks
KW  - Default mode network
KW  - Alzheimer's disease
KW  - Mild cognitive impairment
UR  - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
L2  - http://link.springer.com/article/10.1007%2Fs11910-014-0491-3
N2  - The resting brain exhibits continuous intrinsic activity, which is correlated between groups of regions forming resting state networks. Evaluating resting connectivity is a popular approach for studying brain diseases. Several hundred studies are now available that address integrity of resting connectivity in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as well as preclinical at-risk subjects. Most studies focus on the default mode network, a system of specific brain areas showing strong connected resting activity that attenuates during goal-directed behavior. The extent of intrinsic brain activity tends to be strongly correlated with cognitive processes and is specifically disrupted in AD and MCI patients and at-risk subjects, with changes seeming to evolve during the transition between the disease stages. In this study, we review the current findings in default mode network and other resting state network studies in AD and MCI patients and at-risk subjects as assessed by resting state functional magnetic resonance imaging.
ER  -

KRAJČOVIČOVÁ, Lenka, Radek MAREČEK, Michal MIKL and Irena REKTOROVÁ. Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. \textit{CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS}. NEW YORK: SPRINGER, 2014, vol.~14, No~10, p.~''nestránkované'', 7 pp. ISSN~1528-4042. Available from: https://dx.doi.org/10.1007/s11910-014-0491-3.

Detailed Information on Publication Record