Disturbed Default Mode Network Connectivity Patterns in
Alzheimer's Disease Associated with Visual Processing

J 2014

Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁ

Basic information

Original name

Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

Authors

KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2014, 1387-2877

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.151

RIV identification code

RIV/00216224:14740/14:00074326

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3233/JAD-131208

UT WoS

000340488400019

Keywords in English

Alzheimer's disease; default mode network; functional MRI; posterior cingulate; visual processing

Abstract

V originále

Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD) and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus. Additional connectivity changes (decreases) in AD were present between the posterior cingulate and superior temporal gyrus when switching from baseline to task condition. These changes are probably related to both disturbed visual processing and the DMN connectivity in AD and reflect deficits and compensatory mechanisms within the large scale brain networks in this patient population. Studying the DMN connectivity using psychophysiological interactions analysis may provide a sensitive tool for exploring early changes in AD and their dynamics during the disease progression.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP103/12/0552, research and development project

Name: Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI

Investor: Czech Science Foundation

Citovat

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁ. Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, 2014, vol. 41, No 4, p. 1229-1238. ISSN 1387-2877. Available from: https://dx.doi.org/10.3233/JAD-131208.

@article{1216652,
   author = {Krajčovičová, Lenka and Mikl, Michal and Mareček, Radek and Rektorová, Irena},
   article_location = {AMSTERDAM},
   article_number = {4},
   doi = {http://dx.doi.org/10.3233/JAD-131208},
   keywords = {Alzheimer's disease; default mode network; functional MRI; posterior cingulate; visual processing},
   language = {eng},
   issn = {1387-2877},
   journal = {JOURNAL OF ALZHEIMERS DISEASE},
   title = {Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing},
   url = {https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf},
   volume = {41},
   year = {2014}
}

TY  - JOUR
ID  - 1216652
AU  - Krajčovičová, Lenka - Mikl, Michal - Mareček, Radek - Rektorová, Irena
PY  - 2014
TI  - Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing
JF  - JOURNAL OF ALZHEIMERS DISEASE
VL  - 41
IS  - 4
SP  - 1229-1238
EP  - 1229-1238
PB  - IOS PRESS
SN  - 13872877
KW  - Alzheimer's disease
KW  - default mode network
KW  - functional MRI
KW  - posterior cingulate
KW  - visual processing
UR  - https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf
L2  - https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf
N2  - Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD) and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus. Additional connectivity changes (decreases) in AD were present between the posterior cingulate and superior temporal gyrus when switching from baseline to task condition. These changes are probably related to both disturbed visual processing and the DMN connectivity in AD and reflect deficits and compensatory mechanisms within the large scale brain networks in this patient population. Studying the DMN connectivity using psychophysiological interactions analysis may provide a sensitive tool for exploring early changes in AD and their dynamics during the disease progression.
ER  -

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁ. Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. \textit{JOURNAL OF ALZHEIMERS DISEASE}. AMSTERDAM: IOS PRESS, 2014, vol.~41, No~4, p.~1229-1238. ISSN~1387-2877. Available from: https://dx.doi.org/10.3233/JAD-131208.

Detailed Information on Publication Record