Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

KRAJČOVIČOVÁ, Lenka, Michal MIKL, Radek MAREČEK and Irena REKTOROVÁ. Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, vol. 41, No 4, p. 1229-1238. ISSN 1387-2877. doi:10.3233/JAD-131208. 2014.

Basic information

• Original name: Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing
• Authors: KRAJČOVIČOVÁ, Lenka (703 Slovakia, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2014, 1387-2877.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.151
• RIV identification code: RIV/00216224:14740/14:00074326
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.3233/JAD-131208
• UT WoS: 000340488400019
• Keywords in English: Alzheimer's disease; default mode network; functional MRI; posterior cingulate; visual processing
• Tags: kontrola MP, MP, rivok
• Tags: International impact, Reviewed

Abstract

Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD) and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus. Additional connectivity changes (decreases) in AD were present between the posterior cingulate and superior temporal gyrus when switching from baseline to task condition. These changes are probably related to both disturbed visual processing and the DMN connectivity in AD and reflect deficits and compensatory mechanisms within the large scale brain networks in this patient population. Studying the DMN connectivity using psychophysiological interactions analysis may provide a sensitive tool for exploring early changes in AD and their dynamics during the disease progression.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP103/12/0552, research and development project: Name: Srovnání a inference metod hodnocení funkční a efektivní konektivity ve fMRI

Investor: Czech Science Foundation