REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol. 9, No 1, p. "nestránkované", 8 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595. |
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@article{1216656, author = {Rektorová, Irena and Biundo, Roberta and Mareček, Radek and Weis, Luca and Aarsland, Dag and Antonini, Angelo}, article_location = {SAN FRANCISCO}, article_number = {1}, doi = {http://dx.doi.org/10.1371/journal.pone.0085595}, keywords = {FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA}, language = {eng}, issn = {1932-6203}, journal = {Plos one}, title = {Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients}, url = {http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF}, volume = {9}, year = {2014} }
TY - JOUR ID - 1216656 AU - Rektorová, Irena - Biundo, Roberta - Mareček, Radek - Weis, Luca - Aarsland, Dag - Antonini, Angelo PY - 2014 TI - Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients JF - Plos one VL - 9 IS - 1 SP - "nestránkované" EP - "nestránkované" PB - PUBLIC LIBRARY SCIENCE SN - 19326203 KW - FRONTAL ASSESSMENT BATTERY KW - ITALIAN POPULATION-SAMPLE KW - SOURCE-BASED MORPHOMETRY KW - DEFAULT MODE NETWORK KW - DIAGNOSTIC-CRITERIA KW - ALZHEIMERS-DISEASE KW - NORMATIVE VALUES KW - CEREBRAL ATROPHY KW - LEWY BODIES KW - DEMENTIA UR - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF L2 - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF N2 - Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD. ER -
REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. \textit{Plos one}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol.~9, No~1, p.~''nestránkované'', 8 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595.
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