| REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol. 9, No 1, p. "nestránkované", 8 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595. |
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@article{1216656,
author = {Rektorová, Irena and Biundo, Roberta and Mareček, Radek and Weis, Luca and Aarsland, Dag and Antonini, Angelo},
article_location = {SAN FRANCISCO},
article_number = {1},
doi = {http://dx.doi.org/10.1371/journal.pone.0085595},
keywords = {FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients},
url = {http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF},
volume = {9},
year = {2014}
}
TY - JOUR
ID - 1216656
AU - Rektorová, Irena - Biundo, Roberta - Mareček, Radek - Weis, Luca - Aarsland, Dag - Antonini, Angelo
PY - 2014
TI - Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
JF - Plos one
VL - 9
IS - 1
SP - "nestránkované"
EP - "nestránkované"
PB - PUBLIC LIBRARY SCIENCE
SN - 19326203
KW - FRONTAL ASSESSMENT BATTERY
KW - ITALIAN POPULATION-SAMPLE
KW - SOURCE-BASED MORPHOMETRY
KW - DEFAULT MODE NETWORK
KW - DIAGNOSTIC-CRITERIA
KW - ALZHEIMERS-DISEASE
KW - NORMATIVE VALUES
KW - CEREBRAL ATROPHY
KW - LEWY BODIES
KW - DEMENTIA
UR - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
L2 - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
N2 - Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.
ER -
REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. \textit{Plos one}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol.~9, No~1, p.~''nestránkované'', 8 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595.
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