Grey Matter Changes in Cognitively Impaired Parkinson's Disease
Patients

J 2014

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND et. al.

Basic information

Original name

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

Authors

REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Roberta BIUNDO (380 Italy), Radek MAREČEK (203 Czech Republic, belonging to the institution), Luca WEIS (380 Italy), Dag AARSLAND (752 Sweden) and Angelo ANTONINI (380 Italy)

Edition

Plos one, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2014, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.234

RIV identification code

RIV/00216224:14740/14:00078359

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1371/journal.pone.0085595

UT WoS

000330244500080

Keywords in English

FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA

Abstract

V originále

Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. Plos one. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol. 9, No 1, p. "nestránkované", 8 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595.

@article{1216656,
   author = {Rektorová, Irena and Biundo, Roberta and Mareček, Radek and Weis, Luca and Aarsland, Dag and Antonini, Angelo},
   article_location = {SAN FRANCISCO},
   article_number = {1},
   doi = {http://dx.doi.org/10.1371/journal.pone.0085595},
   keywords = {FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients},
   url = {http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF},
   volume = {9},
   year = {2014}
}

TY  - JOUR
ID  - 1216656
AU  - Rektorová, Irena - Biundo, Roberta - Mareček, Radek - Weis, Luca - Aarsland, Dag - Antonini, Angelo
PY  - 2014
TI  - Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
JF  - Plos one
VL  - 9
IS  - 1
SP  - "nestránkované"
EP  - "nestránkované"
PB  - PUBLIC LIBRARY SCIENCE
SN  - 19326203
KW  - FRONTAL ASSESSMENT BATTERY
KW  - ITALIAN POPULATION-SAMPLE
KW  - SOURCE-BASED MORPHOMETRY
KW  - DEFAULT MODE NETWORK
KW  - DIAGNOSTIC-CRITERIA
KW  - ALZHEIMERS-DISEASE
KW  - NORMATIVE VALUES
KW  - CEREBRAL ATROPHY
KW  - LEWY BODIES
KW  - DEMENTIA
UR  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
L2  - http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0085595&representation=PDF
N2  - Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. Results: We identified two independent patterns of grey matter volume deviations: a) Reductions in the hippocampus and temporal lobes; b) Decreases in fronto-parietal regions and increases in the midbrain/cerebellum. Both patterns differentiated PDD from all other groups and correlated with visuospatial deficits and letter verbal fluency, respectively. Only the second pattern additionally differentiated PD-NC from HC. Conclusion: Grey matter changes in PDD involve areas associated with Alzheimer-like pathology while fronto-parietal abnormalities are possibly an early marker of PD cognitive decline. These findings are consistent with a non-linear cognitive progression in PD.
ER  -

REKTOROVÁ, Irena, Roberta BIUNDO, Radek MAREČEK, Luca WEIS, Dag AARSLAND and Angelo ANTONINI. Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. \textit{Plos one}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2014, vol.~9, No~1, p.~''nestránkované'', 8 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0085595.

Detailed Information on Publication Record