Evaluation of three purely polypropylene meshes of different
pore sizes in an onlay position in a New Zealand white rabbit
model

J 2014

Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model

JEŘÁBEK, Jiří, Tomáš NOVOTNÝ, Karel VESELÝ, Jan CAGAŠ, Václav JEDLIČKA et. al.

Basic information

Original name

Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model

Authors

JEŘÁBEK, Jiří (203 Czech Republic, guarantor, belonging to the institution), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Karel VESELÝ (203 Czech Republic, belonging to the institution), Jan CAGAŠ (203 Czech Republic, belonging to the institution), Václav JEDLIČKA (203 Czech Republic, belonging to the institution), Petr VLČEK (203 Czech Republic, belonging to the institution) and Ivan ČAPOV (203 Czech Republic, belonging to the institution)

Edition

Hernia, New York, Springer, 2014, 1265-4906

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.050

RIV identification code

RIV/00216224:14110/14:00078365

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10029-014-1278-9

UT WoS

000345702100013

Keywords in English

Hernia; Polypropylene mesh; Pore size; Shrinkage; Abdominal wall compliance; Foreign body reaction

Abstract

V originále

The aim of the study was to evaluate the influence of the pore size of a polypropylene mesh on the shrinkage and elasticity of the mesh-tissue complex and the inflammatory reaction to the implant in an open onlay hernia repair. Twenty-one 10 x 10 cm samples of polypropylene meshes of a different pore size (3.0 x 2.8 mm-PP3, 1.0 x 0.8 mm-PP1 and 0.6 x 0.5 mm-PP.5) were implanted in an onlay position in 21 New Zealand white rabbits. After 90 days of implantation the shrinkage, elasticity and foreign body reaction (FBR) were assessed. The shrinkage of PP3 was 30.6 +/- A 4.3 %, PP1 49.3 +/- A 2.9 % and PP.5 49.5 +/- A 2.6 %. The shrinkage of PP3 was significantly lower (PP3 x PP1 p = 0.007, PP3 x PP.5 p = 0.005), PP1 and PP.5 were similar. The elasticity was similar. The strength of FBR in mesh pores was similar. The width of foreign body granuloma layers at the mesh-tissue interface was significantly reduced with increasing pore size (inner: PP3 10.1 +/- A 1.2; PP1 12.5 +/- A 2.9; PP.5 17.4 +/- A 5.2 and outer: PP3 21.2 +/- A 2.5; PP1 30.6 +/- A 6.3; PP.5 60.4 +/- A 14.9). All differences between the widths of granuloma layers were statistically significant (p < 0.010). One animal (PP1) was excluded because of a mesh infection. Implantation of polypropylene mesh of a pore size of 3 mm in an onlay position is associated with a significant reduction of shrinkage in comparison to a 1 mm pore lightweight and 0.5 mm pore heavyweight mesh. A pore size increase to 3 mm is not sufficient for an improvement of mesh-tissue complex elasticity in comparison to a 1 mm pore lightweight and 0.5 mm heavyweight mesh. Polypropylene mesh with enlarged pores to 3 mm is associated with a similar strength of FBR in mesh pores and a reduced foreign body granuloma in comparison to a 1 mm pore lightweight and 0.5 mm pore heavyweight mesh.

Citovat

JEŘÁBEK, Jiří, Tomáš NOVOTNÝ, Karel VESELÝ, Jan CAGAŠ, Václav JEDLIČKA, Petr VLČEK and Ivan ČAPOV. Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model. Hernia. New York: Springer, 2014, vol. 18, No 6, p. 855-864. ISSN 1265-4906. Available from: https://dx.doi.org/10.1007/s10029-014-1278-9.

@article{1216678,
   author = {Jeřábek, Jiří and Novotný, Tomáš and Veselý, Karel and Cagaš, Jan and Jedlička, Václav and Vlček, Petr and Čapov, Ivan},
   article_location = {New York},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s10029-014-1278-9},
   keywords = {Hernia; Polypropylene mesh; Pore size; Shrinkage; Abdominal wall compliance; Foreign body reaction},
   language = {eng},
   issn = {1265-4906},
   journal = {Hernia},
   title = {Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model},
   volume = {18},
   year = {2014}
}

TY  - JOUR
ID  - 1216678
AU  - Jeřábek, Jiří - Novotný, Tomáš - Veselý, Karel - Cagaš, Jan - Jedlička, Václav - Vlček, Petr - Čapov, Ivan
PY  - 2014
TI  - Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model
JF  - Hernia
VL  - 18
IS  - 6
SP  - 855-864
EP  - 855-864
PB  - Springer
SN  - 12654906
KW  - Hernia
KW  - Polypropylene mesh
KW  - Pore size
KW  - Shrinkage
KW  - Abdominal wall compliance
KW  - Foreign body reaction
N2  - The aim of the study was to evaluate the influence of the pore size of a polypropylene mesh on the shrinkage and elasticity of the mesh-tissue complex and the inflammatory reaction to the implant in an open onlay hernia repair. Twenty-one 10 x 10 cm samples of polypropylene meshes of a different pore size (3.0 x 2.8 mm-PP3, 1.0 x 0.8 mm-PP1 and 0.6 x 0.5 mm-PP.5) were implanted in an onlay position in 21 New Zealand white rabbits. After 90 days of implantation the shrinkage, elasticity and foreign body reaction (FBR) were assessed. The shrinkage of PP3 was 30.6 +/- A 4.3 %, PP1 49.3 +/- A 2.9 % and PP.5 49.5 +/- A 2.6 %. The shrinkage of PP3 was significantly lower (PP3 x PP1 p = 0.007, PP3 x PP.5 p = 0.005), PP1 and PP.5 were similar. The elasticity was similar. The strength of FBR in mesh pores was similar. The width of foreign body granuloma layers at the mesh-tissue interface was significantly reduced with increasing pore size (inner: PP3 10.1 +/- A 1.2; PP1 12.5 +/- A 2.9; PP.5 17.4 +/- A 5.2 and outer: PP3 21.2 +/- A 2.5; PP1 30.6 +/- A 6.3; PP.5 60.4 +/- A 14.9). All differences between the widths of granuloma layers were statistically significant (p < 0.010). One animal (PP1) was excluded because of a mesh infection. Implantation of polypropylene mesh of a pore size of 3 mm in an onlay position is associated with a significant reduction of shrinkage in comparison to a 1 mm pore lightweight and 0.5 mm pore heavyweight mesh. A pore size increase to 3 mm is not sufficient for an improvement of mesh-tissue complex elasticity in comparison to a 1 mm pore lightweight and 0.5 mm heavyweight mesh. Polypropylene mesh with enlarged pores to 3 mm is associated with a similar strength of FBR in mesh pores and a reduced foreign body granuloma in comparison to a 1 mm pore lightweight and 0.5 mm pore heavyweight mesh.
ER  -

JEŘÁBEK, Jiří, Tomáš NOVOTNÝ, Karel VESELÝ, Jan CAGAŠ, Václav JEDLIČKA, Petr VLČEK and Ivan ČAPOV. Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model. \textit{Hernia}. New York: Springer, 2014, vol.~18, No~6, p.~855-864. ISSN~1265-4906. Available from: https://dx.doi.org/10.1007/s10029-014-1278-9.

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