Pupilární reakce na barevné podněty

SKORKOVSKÁ, Karolína, F. MAEDA, C. KELBSCH, T. PETERS, B. WILHELM and H. WILHELM. Pupilární reakce na barevné podněty (Pupillary Response to Chromatic Stimuli). Česká a Slovenská neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E. Purkyně, 2014, vol. 77, No 3, p. 334-338. ISSN 1210-7859.

Basic information

Original name

Pupilární reakce na barevné podněty

Name (in English)

Pupillary Response to Chromatic Stimuli

Authors

SKORKOVSKÁ, Karolína (203 Czech Republic, guarantor, belonging to the institution), F. MAEDA (276 Germany), C. KELBSCH (276 Germany), T. PETERS (276 Germany), B. WILHELM (276 Germany) and H. WILHELM (276 Germany)

Edition

Česká a Slovenská neurologie a neurochirurgie, Praha, Česká lékařská společnost J.E. Purkyně, 2014, 1210-7859

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Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.165

RIV identification code

RIV/00216224:14110/14:00078374

Organization unit

Faculty of Medicine

UT WoS

000336563200010

Keywords in English

pupillary reflex; melanopsin; photoreceptor cells

Tags

EL OK

Tags

International impact, Reviewed

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Abstract

V originále

Aim of study: To compare chromatic pupillary responses in a group of healthy subjects and to determine if this method can be used for assessing outer and inner retinal function. Material and methods: The study group consisted of 17 healthy subjects. Subjects were tested with a chromatic pupillometer. The parameters of the stimulus were as follows: intensity 28 lx, duration 4 sec, and color blue (420 +/- 20 nm) and red (605 +/- 20 nm). The examined pupil parameters were baseline pupil diameter, maximal constriction time, relative amplitude at maximal constriction, at 3 sec after stimulus onset, at stimulus offset, at 3 sec after stimulus offset and at 7 sec after stimulus offset. Pupil response parameters to red and blue light were evaluated by paired t-test. Results: Except for the baseline pupil diameter (p = 0.148), there was a significant difference in all pupil response parameters to red and blue light (p = 0.001). With blue light, the relative amplitude was significantly greater and the time to maximal pupil constriction significantly longer compared to red light for all tested time points. Blue light evoked "sustained" pupil contraction, while red light rather induced "transient" contraction. Conclusions: Our examination protocol allowed us to unmask differences in pupil response to red and blue light in healthy subjects and to confirm involvement of the melanopsin retinal ganglion cells in the pupil light reflex, particularly with blue light. Chromatic pupillography appears to be a highly sensitive method for objective evaluation of the outer and inner retina function.

In English

Aim of study: To compare chromatic pupillary responses in a group of healthy subjects and to determine if this method can be used for assessing outer and inner retinal function. Material and methods: The study group consisted of 17 healthy subjects. Subjects were tested with a chromatic pupillometer. The parameters of the stimulus were as follows: intensity 28 lx, duration 4 sec, and color blue (420 +/- 20 nm) and red (605 +/- 20 nm). The examined pupil parameters were baseline pupil diameter, maximal constriction time, relative amplitude at maximal constriction, at 3 sec after stimulus onset, at stimulus offset, at 3 sec after stimulus offset and at 7 sec after stimulus offset. Pupil response parameters to red and blue light were evaluated by paired t-test. Results: Except for the baseline pupil diameter (p = 0.148), there was a significant difference in all pupil response parameters to red and blue light (p = 0.001). With blue light, the relative amplitude was significantly greater and the time to maximal pupil constriction significantly longer compared to red light for all tested time points. Blue light evoked "sustained" pupil contraction, while red light rather induced "transient" contraction. Conclusions: Our examination protocol allowed us to unmask differences in pupil response to red and blue light in healthy subjects and to confirm involvement of the melanopsin retinal ganglion cells in the pupil light reflex, particularly with blue light. Chromatic pupillography appears to be a highly sensitive method for objective evaluation of the outer and inner retina function.