DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia

VALENT, Peter, Irina SADOVNIK, Zdeněk RÁČIL, Harald HERRMANN, Katharina BLATT, Sabine CERNY-REITERER, Gregor EISENWORT, Thomas LION, Tessa HOLYOAKE and Jiří MAYER. DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia. European Journal of Clinical Investigation. HOBOKEN: WILEY-BLACKWELL, 2014, vol. 44, No 12, p. 1239-1245. ISSN 0014-2972. Available from: https://dx.doi.org/10.1111/eci.12368.

Basic information

• Original name: DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia
• Authors: VALENT, Peter (40 Austria), Irina SADOVNIK (40 Austria), Zdeněk RÁČIL (203 Czech Republic, guarantor, belonging to the institution), Harald HERRMANN (40 Austria), Katharina BLATT (40 Austria), Sabine CERNY-REITERER (40 Austria), Gregor EISENWORT (40 Austria), Thomas LION (40 Austria), Tessa HOLYOAKE (826 United Kingdom of Great Britain and Northern Ireland) and Jiří MAYER (203 Czech Republic, belonging to the institution).
• Edition: European Journal of Clinical Investigation, HOBOKEN, WILEY-BLACKWELL, 2014, 0014-2972.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.734
• RIV identification code: RIV/00216224:14110/14:00078413
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/eci.12368
• UT WoS: 000345759100012
• Keywords in English: Diagnostics; leukaemia; leukaemic stem cells; stem cell; phenotyping
• Tags: EL OK, ok, RIV
• Tags: International impact, Reviewed

Abstract

The concept of leukaemic stem cells (LSCs) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through LSC eradication in these patients. Some of the newly discovered LSC markers seem to be expressed in a disease-specific manner and may thus serve as major research tools and diagnostic parameters. A useful LSC marker in chronic myeloid leukaemia (CML) appears to be CD26, also known as dipeptidylpeptidase IV. Expression of CD26 is largely restricted to CD34(+)/CD38(-) LSCs in BCR/ABL1(+) CML, but is not found on LSCs in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of CML, BCR/ABL1(p210)+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, CD26 usually is not expressed on normal bone marrow (BM) stem cells. Functionally, CD26 is a cytokine-targeting surface enzyme that may facilitate the mobilization of LSCs from the BM niche. In this article, we review our current knowledge about the biology and function of CD26 on CML LSCs and discuss the diagnostic potential of this new LSC marker in clinical haematology.