DOLEŽALOVÁ, Irena, Milan BRÁZDIL, Markéta HERMANOVÁ, Eva JANOUŠOVÁ a Robert KUBA. Effect of partial drug withdrawal on the lateralization of interictal epileptiform discharges and its relationship to surgical outcome in patients with hippocampal sclerosis. Epilepsy Research. Amsterdam: Elsevier Science, 2014, roč. 108, č. 8, s. 1406-1416. ISSN 0920-1211. doi:10.1016/j.eplepsyres.2014.06.009.
Další formáty:   BibTeX LaTeX RIS
Základní údaje
Originální název Effect of partial drug withdrawal on the lateralization of interictal epileptiform discharges and its relationship to surgical outcome in patients with hippocampal sclerosis
Autoři DOLEŽALOVÁ, Irena (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, garant, domácí), Markéta HERMANOVÁ (203 Česká republika, domácí), Eva JANOUŠOVÁ (203 Česká republika, domácí) a Robert KUBA (203 Česká republika, domácí).
Vydání Epilepsy Research, Amsterdam, Elsevier Science, 2014, 0920-1211.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 2.015
Kód RIV RIV/00216224:14740/14:00078425
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1016/j.eplepsyres.2014.06.009
UT WoS 000342269000018
Klíčová slova anglicky Epilepsy; Hippocampal sclerosis; Outcome; Interictal epileptiform discharges (IEDs); Unitemporal IEDs; Bitemporal IEDs
Štítky EL OK, kontrola MP, MP, podil, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Martina Prášilová, učo 342282. Změněno: 26. 1. 2015 10:39.
Anotace
Objective: To assess changes in the relative lateralization of interictal epileptiform discharges (IEDs) and interictal EEG prognostic value in terms of surgical outcome between periods with full medication (FMP) and reduced medication (RMP) in patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS). Methods: Interictal scalp EEGs of 43 patients were evaluated for the presence of IEDs separately in a waking state (WS) and sleeping state (SS) during FMP and RMP. In each period, patients were categorized as having unitemporal or bitemporal IEDs. Surgical outcome was classified at year 1 after surgery and at last follow-up visit as Engel I or Engel II-IV; and alternatively as completely seizure-free or not seizure-free. Results: There were significant changes in relative IED lateralization between FMP and RMP during SS. The representation of patients with unitemporal IEDs declined from 37 (86%) in FMP during SS to 25 (58%) in RMP during SS (p = 0.003). At year 1 after surgery, the relative IED lateralization is a predictive factor for surgical outcome defined as Engel I vs. Engel II-IV in both FMP during WS (p = 0.037) and during SS (p = 0.007), and for surgical outcome defined as completely seizure-free vs. not seizure-free in FMP during SS (p = 0.042). At last follow up visit, the relative IED lateralization is a predictor for outcome defined as Engel I vs. Engel II-IV in FMP during SS (p = 0.020), and for outcome defined as completely seizure-free vs. not seizure-free in both FMP during WS (p = 0.043) and in FMP during SS (p = 0.015). When stepwise logistic regression analysis was applied, only FMP during SS was found to be an independent predictor for surgical outcome at year 1 after surgery (completely seizure-free vs. not seizure-free p = 0.032, Engel I vs. Engel II-IV p = 0.006) and at last follow-up visit (completely seizure-free vs. not seizure-free p = 0.024, Engel I vs. Engel II-IV p = 0.017). Gender was found to be independent predictor for surgical efficacy at year 1 if the outcome was defined as completely seizure-free vs. not seizure-free (p = 0.036). Conclusion: The predictive value of relative IED lateralization with respect to surgical outcome in interictal EEG is present only during FMP; the predictive value decreases with the reduction of AEDs caused by the change of relative IED lateralization. (C) 2014 Elsevier B.V. All rights reserved.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
VytisknoutZobrazeno: 30. 6. 2022 14:59