LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ a Alexandra ŠULCOVÁ. Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice. Veterinarni Medicina. Prague: Czech Academy of Agricultural Sciences, 2014, roč. 59, č. 6, s. 307-314. ISSN 0375-8427.
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Základní údaje
Originální název Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
Autoři LANDA, Leoš (203 Česká republika, domácí), Karel ŠLAIS (203 Česká republika, domácí), Alena MÁCHALOVÁ (203 Česká republika, domácí) a Alexandra ŠULCOVÁ (203 Česká republika, garant, domácí).
Vydání Veterinarni Medicina, Prague, Czech Academy of Agricultural Sciences, 2014, 0375-8427.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30104 Pharmacology and pharmacy
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 0.639
Kód RIV RIV/00216224:14110/14:00078460
Organizační jednotka Lékařská fakulta
UT WoS 000342070600006
Klíčová slova anglicky behavioural sensitisation; morphine; cannabinoids; ACPA; mice
Štítky EL OK, podil
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Ing. Mgr. Věra Pospíšilíková, učo 9005. Změněno: 18. 1. 2015 16:57.
Anotace
Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not yet fully understood. Thus, the aim of the present study was to investigate the interaction between morphine and the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) in behavioural sensitisation. Sensitisation occurs after repeated exposure to drugs of abuse including morphine and cannabinomimetics and it has been suggested to mediate craving and relapses. Male mice were randomly allocated into three groups and were seven times (from the 7th to 13th day of the experiment) administered drugs as follows: (a) n(1): vehicle at the dose of 10 ml/kg/day; (b) n(2): morphine at the dose of 10.0 mg/kg/day; (c) n(3): ACPA at the dose of 1.0 mg/kg/day. Changes in locomotor behaviour were measured in the Open Field Test: (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after "challenge doses" given in the following way: n(1): saline at the dose of 10 ml/kg, n(2, 3): morphine at the dose of 10.0 mg/kg. Registered behavioural changes unambiguously showed the development of behavioural sensitisation to the stimulatory effects of morphine on locomotion after its repeated administration (P < 0.05). However, surprisingly, taking into account reports on synergistic effects of opioids and cannabinoid receptor stimulation, a significant decrease (P < 0.05) in behavioural sensitisation to morphine occurred when the drug challenge dose was given following repeated pre-treatment with the CB1 receptor agonist ACPA, i.e. suppression of cross-sensitisation to morphine.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
VytisknoutZobrazeno: 26. 6. 2022 01:02