LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁ. Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice. Veterinarni Medicina. Prague: Czech Academy of Agricultural Sciences, 2014, vol. 59, No 6, p. 307-314. ISSN 0375-8427.
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Basic information
Original name Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
Authors LANDA, Leoš (203 Czech Republic, belonging to the institution), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Veterinarni Medicina, Prague, Czech Academy of Agricultural Sciences, 2014, 0375-8427.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.639
RIV identification code RIV/00216224:14110/14:00078460
Organization unit Faculty of Medicine
UT WoS 000342070600006
Keywords in English behavioural sensitisation; morphine; cannabinoids; ACPA; mice
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 18. 1. 2015 16:57.
Abstract
Activities of the endocannabinoid system are believed to be substantially involved in psychostimulant and opioid addiction. Nevertheless, interactions between cannabinoid and opioid systems are not yet fully understood. Thus, the aim of the present study was to investigate the interaction between morphine and the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) in behavioural sensitisation. Sensitisation occurs after repeated exposure to drugs of abuse including morphine and cannabinomimetics and it has been suggested to mediate craving and relapses. Male mice were randomly allocated into three groups and were seven times (from the 7th to 13th day of the experiment) administered drugs as follows: (a) n(1): vehicle at the dose of 10 ml/kg/day; (b) n(2): morphine at the dose of 10.0 mg/kg/day; (c) n(3): ACPA at the dose of 1.0 mg/kg/day. Changes in locomotor behaviour were measured in the Open Field Test: (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after "challenge doses" given in the following way: n(1): saline at the dose of 10 ml/kg, n(2, 3): morphine at the dose of 10.0 mg/kg. Registered behavioural changes unambiguously showed the development of behavioural sensitisation to the stimulatory effects of morphine on locomotion after its repeated administration (P < 0.05). However, surprisingly, taking into account reports on synergistic effects of opioids and cannabinoid receptor stimulation, a significant decrease (P < 0.05) in behavioural sensitisation to morphine occurred when the drug challenge dose was given following repeated pre-treatment with the CB1 receptor agonist ACPA, i.e. suppression of cross-sensitisation to morphine.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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