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@article{1217404,
author = {Litzman, Jiří},
article_location = {Hoboken},
article_number = {Suppl. S1},
doi = {http://dx.doi.org/10.1111/cei.12529},
keywords = {FCRN; intravenous immunoglobulin catabolism},
language = {eng},
issn = {0009-9104},
journal = {Clinical & Experimental Immunology},
title = {Influence of FCRN expression on lung decline and intravenous immunoglobulin catabolism in common variable immunodeficiency patients},
volume = {178},
year = {2014}
}
TY - JOUR
ID - 1217404
AU - Litzman, Jiří
PY - 2014
TI - Influence of FCRN expression on lung decline and intravenous immunoglobulin catabolism in common variable immunodeficiency patients
JF - Clinical & Experimental Immunology
VL - 178
IS - Suppl. S1
SP - 103-104
EP - 103-104
PB - Wiley-Blackwell
SN - 00099104
KW - FCRN
KW - intravenous immunoglobulin catabolism
N2 - The neonatal Fc receptor (FcRn) was first described as a receptor-mediating transplacental immunoglobulin (Ig)G transfer from mother to fetus, but it has other significant biological functions. It plays a key role in IgG and albumin homeostasis by efficient protection from catabolism [1]. It binds endocytosed IgG at acidic pH (< 6·5) within endosomes, diverts it from degradation in lysosomes and instead transports the IgG–FcRn complexes back to the cell surface where, at neutral pH (> 7·0), IgG is released [1]. This process is highly efficient; FcRn recycles an equivalent amount of albumin and even four times as much IgG as can be produced in a given time [2,3].
ER -
LITZMAN, Jiří. Influence of FCRN expression on lung decline and intravenous immunoglobulin catabolism in common variable immunodeficiency patients. \textit{Clinical \&{} Experimental Immunology}. Hoboken: Wiley-Blackwell, roč.~178, Suppl. S1, s.~103-104. ISSN~0009-9104. doi:10.1111/cei.12529. 2014.
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