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@article{1217783,
author = {Heger, Zbynek and Cernei, Natalia and Blazkova, Iva and Kopel, Petr and Masařík, Michal and Zitka, Ondrej and Adam, Vojtech and Kizek, Rene},
article_location = {Heidelberg},
article_number = {21-22},
doi = {http://dx.doi.org/10.1007/s10337-014-2732-7},
keywords = {Excitation; HEK-239; Luminescence; Nanoconjugate; Theranostics},
language = {eng},
issn = {0009-5893},
journal = {Chromatographia},
title = {gamma-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter},
volume = {77},
year = {2014}
}
TY - JOUR
ID - 1217783
AU - Heger, Zbynek - Cernei, Natalia - Blazkova, Iva - Kopel, Petr - Masařík, Michal - Zitka, Ondrej - Adam, Vojtech - Kizek, Rene
PY - 2014
TI - gamma-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter
JF - Chromatographia
VL - 77
IS - 21-22
SP - 1415-1423
EP - 1415-1423
PB - Springer
SN - 00095893
KW - Excitation
KW - HEK-239
KW - Luminescence
KW - Nanoconjugate
KW - Theranostics
N2 - The present paper describes the synthesis, characterization, and utilization of multi-functional magnetic conjugates that integrate optical and magnetic properties in a single structure for use in many biomedical applications. Spontaneous interaction with eukaryotic cell membrane (HEK-239 cell culture) was determined using fluorescence microscopy, and fluorescence analyses. Both, differences in excitation, and emission wavelength were observed, caused by glutathione intake by cells, resulting in disintegration of core-shell structure of quantum dots, as well as adhesion of conjugate onto cell surface. When compared with quantum dots fluorescent properties, HEK-239 cells with incorporated nanoconjugate exhibited two excitation maxima (lambda (ex) = 430 and 390 nm). Simultaneously, application of ideal lambda (ex) for quantum dots (lambda (ex) = 430 nm), resulted in two emission maxima (lambda = 740 and 750 nm). This nanoconjugate fulfills the requirements of term theranostics, because it can be further functionalized with biomolecules as DNA, proteins, peptides or antibodies, and thus serves as a tool for therapy in combination with simultaneous treatment.
ER -
HEGER, Zbynek, Natalia CERNEI, Iva BLAZKOVA, Petr KOPEL, Michal MASAŘÍK, Ondrej ZITKA, Vojtech ADAM and Rene KIZEK. gamma-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter. \textit{Chromatographia}. Heidelberg: Springer, 2014, vol.~77, 21-22, p.~1415-1423. ISSN~0009-5893. Available from: https://dx.doi.org/10.1007/s10337-014-2732-7.
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