MAGEROVA, Hana, Martin VYHNALEK, Jan LACZO, Ross ANDEL, Irena REKTOROVÁ, Alexandra KADLECOVA, Martin BOJAR and Jakub HORT. Odor Identification in Frontotemporal Lobar Degeneration Subtypes. American Journal of Alzheimer's Disease and other Dementias. Thousand Oaks: SAGE Publications Inc., 2014, vol. 29, No 8, p. 762-768. ISSN 1533-3175. Available from: https://dx.doi.org/10.1177/1533317514539033.
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Basic information
Original name Odor Identification in Frontotemporal Lobar Degeneration Subtypes
Authors MAGEROVA, Hana (203 Czech Republic), Martin VYHNALEK (203 Czech Republic), Jan LACZO (203 Czech Republic), Ross ANDEL (840 United States of America), Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution), Alexandra KADLECOVA (203 Czech Republic), Martin BOJAR (203 Czech Republic) and Jakub HORT (203 Czech Republic).
Edition American Journal of Alzheimer's Disease and other Dementias, Thousand Oaks, SAGE Publications Inc. 2014, 1533-3175.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.627
RIV identification code RIV/00216224:14110/14:00078744
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1177/1533317514539033
UT WoS 000345335300017
Keywords in English odor identification; behavioral variant frontotemporal dementia; primary nonfluent aphasia; semantic dementia; progressive supranuclear palsy; cognitive status
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 27/1/2015 18:35.
Abstract
Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline.
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