LOX/COX inhibitors enhance the antineoplastic effects of
all-trans retinoic acid in osteosarcoma cell lines.

J 2014

LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.

KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL et. al.

Basic information

Original name

LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.

Authors

KRZYŽÁNKOVÁ, Miroslava (703 Slovakia, belonging to the institution), Silvia CHOVANOVÁ (703 Slovakia, belonging to the institution), Petr CHLAPEK (203 Czech Republic, belonging to the institution), Matěj RÁDSETOULAL (203 Czech Republic, belonging to the institution), Jakub NERADIL (203 Czech Republic, belonging to the institution), Karel ZITTERBART (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution) and Renata VESELSKÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Tumor Biology, Dordrecht, Springer, 2014, 1010-4283

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

40101 Agriculture

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.611

RIV identification code

RIV/00216224:14310/14:00079005

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s13277-014-2019-5

UT WoS

000341883500046

Keywords in English

osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation

Abstract

V originále

In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors.

Links

EE2.3.20.0183, research and development project

Name: Centrum experimentální biomedicíny

2SGA2834, interní kód MU

Name: Cellular and molecular responses induced by combined application of differentiating and antiangiogenic agents in sarcoma cell lines (Acronym: SARCOMBAT)

Investor: South-Moravian Region, Incoming grants

Citovat

KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL, Karel ZITTERBART, Jaroslav ŠTĚRBA and Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. Tumor Biology. Dordrecht: Springer, 2014, vol. 35, No 8, p. 7617-7627. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-014-2019-5.

@article{1225458,
   author = {Krzyžánková, Miroslava and Chovanová, Silvia and Chlapek, Petr and Rádsetoulal, Matěj and Neradil, Jakub and Zitterbart, Karel and Štěrba, Jaroslav and Veselská, Renata},
   article_location = {Dordrecht},
   article_number = {8},
   doi = {http://dx.doi.org/10.1007/s13277-014-2019-5},
   keywords = {osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.},
   url = {http://link.springer.com/article/10.1007%2Fs13277-014-2019-5},
   volume = {35},
   year = {2014}
}

TY  - JOUR
ID  - 1225458
AU  - Krzyžánková, Miroslava - Chovanová, Silvia - Chlapek, Petr - Rádsetoulal, Matěj - Neradil, Jakub - Zitterbart, Karel - Štěrba, Jaroslav - Veselská, Renata
PY  - 2014
TI  - LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.
JF  - Tumor Biology
VL  - 35
IS  - 8
SP  - 7617-7627
EP  - 7617-7627
PB  - Springer
SN  - 10104283
KW  - osteosarcoma
KW  - all-trans retinoic acid
KW  - caffeic acid
KW  - celecoxib
KW  - osteogenic differentiation
UR  - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
L2  - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
N2  - In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors.
ER  -

KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL, Karel ZITTERBART, Jaroslav ŠTĚRBA and Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. \textit{Tumor Biology}. Dordrecht: Springer, 2014, vol.~35, No~8, p.~7617-7627. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-014-2019-5.

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