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@article{1225458,
author = {Krzyžánková, Miroslava and Chovanová, Silvia and Chlapek, Petr and Rádsetoulal, Matěj and Neradil, Jakub and Zitterbart, Karel and Štěrba, Jaroslav and Veselská, Renata},
article_location = {Dordrecht},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s13277-014-2019-5},
keywords = {osteosarcoma; all-trans retinoic acid; caffeic acid; celecoxib; osteogenic differentiation},
language = {eng},
issn = {1010-4283},
journal = {Tumor Biology},
title = {LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.},
url = {http://link.springer.com/article/10.1007%2Fs13277-014-2019-5},
volume = {35},
year = {2014}
}
TY - JOUR
ID - 1225458
AU - Krzyžánková, Miroslava - Chovanová, Silvia - Chlapek, Petr - Rádsetoulal, Matěj - Neradil, Jakub - Zitterbart, Karel - Štěrba, Jaroslav - Veselská, Renata
PY - 2014
TI - LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.
JF - Tumor Biology
VL - 35
IS - 8
SP - 7617-7627
EP - 7617-7627
PB - Springer
SN - 10104283
KW - osteosarcoma
KW - all-trans retinoic acid
KW - caffeic acid
KW - celecoxib
KW - osteogenic differentiation
UR - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
L2 - http://link.springer.com/article/10.1007%2Fs13277-014-2019-5
N2 - In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors.
ER -
KRZYŽÁNKOVÁ, Miroslava, Silvia CHOVANOVÁ, Petr CHLAPEK, Matěj RÁDSETOULAL, Jakub NERADIL, Karel ZITTERBART, Jaroslav ŠTĚRBA and Renata VESELSKÁ. LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines. \textit{Tumor Biology}. Dordrecht: Springer, 2014, vol.~35, No~8, p.~7617-7627. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-014-2019-5.
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