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@article{1226580,
author = {Konecny, Tomas and Geske, Jeffrey B. and Ludka, Ondřej and Orban, Marek and Brady, Peter A. and Abudiab, Muaz M. and Albuquerque, Felipe N. and Placek, Alexander and Kara, Tomas and Sahakyan, Karine R. and Gersh, Bernard J. and Tajik, A. Jamil and Allison, Thomas G. and Ommen, Steve R. and Somers, Virend K.},
article_location = {Glenview},
article_number = {6},
doi = {http://dx.doi.org/10.1378/chest.14-1498},
keywords = {CARDIOPULMONARY EXERCISE; ATRIAL-FIBRILLATION; APNEA SYNDROME; TASK-FORCE; ASSOCIATION; CARDIOLOGY; DIAGNOSIS; OXIMETRY; THERAPY; PREVALENCE},
language = {eng},
issn = {0012-3692},
journal = {Chest},
title = {Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy},
url = {http://journal.publications.chestnet.org/article.aspx?articleid=2107856},
volume = {147},
year = {2015}
}
TY - JOUR
ID - 1226580
AU - Konecny, Tomas - Geske, Jeffrey B. - Ludka, Ondřej - Orban, Marek - Brady, Peter A. - Abudiab, Muaz M. - Albuquerque, Felipe N. - Placek, Alexander - Kara, Tomas - Sahakyan, Karine R. - Gersh, Bernard J. - Tajik, A. Jamil - Allison, Thomas G. - Ommen, Steve R. - Somers, Virend K.
PY - 2015
TI - Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy
JF - Chest
VL - 147
IS - 6
SP - 1574-1581
EP - 1574-1581
PB - American College of Chest Physicians
SN - 00123692
KW - CARDIOPULMONARY EXERCISE
KW - ATRIAL-FIBRILLATION
KW - APNEA SYNDROME
KW - TASK-FORCE
KW - ASSOCIATION
KW - CARDIOLOGY
KW - DIAGNOSIS
KW - OXIMETRY
KW - THERAPY
KW - PREVALENCE
UR - http://journal.publications.chestnet.org/article.aspx?articleid=2107856
N2 - BACKGROUND: Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SDB in the attenuated exercise capacity in HCM has not been studied previously. METHODS: Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB was considered present if the oxygen desaturation index (number of >= 4% desaturations/h) was >= 10. Peak oxygen consumption ((V) over doto(2)peak) (the most reproducible and prognostic measure of cardiovascular fitness) was then correlated with the presence and severity of SDB. RESULTS: A total of 198 patients with HCM were studied (age, 53 +/- 16 years; 122 men), of whom 32% met the criteria for the SDB diagnosis. Patients with SDB had decreased (V) over doto(2)peak compared with those without SDB (16 mL O-2/kg/min vs 21 mL O-2/kg/min, P < .001). SDB remained significantly associated with (V) over doto(2)peak aft er accounting for confounding clinical variables (P < .001) including age, sex, BMI, atrial fibrillation, and coronary artery disease. CONCLUSIONS: In patients with HCM, the presence of SDB is associated with decreased (V) over doto(2)peak. SDB may represent an important and potentially modifiable contributor to impaired exercise tolerance in this unique population.
ER -
KONECNY, Tomas, Jeffrey B. GESKE, Ondřej LUDKA, Marek ORBAN, Peter A. BRADY, Muaz M. ABUDIAB, Felipe N. ALBUQUERQUE, Alexander PLACEK, Tomas KARA, Karine R. SAHAKYAN, Bernard J. GERSH, A. Jamil TAJIK, Thomas G. ALLISON, Steve R. OMMEN and Virend K. SOMERS. Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy. \textit{Chest}. Glenview: American College of Chest Physicians, 2015, vol.~147, No~6, p.~1574-1581. ISSN~0012-3692. Available from: https://dx.doi.org/10.1378/chest.14-1498.
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