J 2014

Epigenetic Regulation of Telomere Maintenance

FOJTOVÁ, Miloslava and Jiří FAJKUS

Basic information

Original name

Epigenetic Regulation of Telomere Maintenance

Authors

FOJTOVÁ, Miloslava (203 Czech Republic, belonging to the institution) and Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cytogenetic and Genome research, Basel, Karger, 2014, 1424-8581

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.561

RIV identification code

RIV/00216224:14740/14:00074401

Organization unit

Central European Institute of Technology

DOI

UT WoS

000342614100013

Keywords in English

Chromatin; DNA methylation; Epigenetics; Histone modifications; Telomerase; Telomere; Telomeric transcripts

Tags

Tags

International impact, Reviewed
Změněno: 23/2/2015 08:53, Martina Prášilová

Abstract

V originále

As chromatin structures, telomeres undergo epigenetic regulation of their maintenance and function. In plants, these processes are likely of a higher complexity than in animals or yeasts, as exemplified by methylation of cytosines in plant telomeric DNA or reversible developmental regulation of plant telomerase. We highlight the dual role of telomeres from the epigenetic point of view: (i) as chromatin structures that are the subject of epigenetic regulation (e. g. DNA and histone modifications), and (ii) as chromosome domains acting themselves as epigenetic regulatory elements (e. g. in the telomere position effect). Possibly, some molecular tools (e. g. telomeric transcripts) are common to both these aspects of telomere epigenetics. We further discuss the justification for the classical textbook view of telomeres as heterochromatic structures. (C) 2014 S. Karger AG, Basel

Links

ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology
EE2.3.20.0043, research and development project
Name: Rozvoj lidských zdrojů pro výzkum, vývoj a inovace v oblasti genomiky a proteomiky rostlinných systémů
EE2.3.20.0189, research and development project
Name: Rozvoj výzkumné excelence v oblasti evoluční cytogenomiky, epigenetiky a buněčné signalizace
GAP501/11/0289, research and development project
Name: Ztráta specifických repetic DNA v důsledku dysfunkce CAF1 u rostlin
Investor: Czech Science Foundation
GAP501/11/0596, research and development project
Name: Epigenetické mechanismy regulace rostlinných telomer (Acronym: epigenetika telomer)
Investor: Czech Science Foundation