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@article{1227550, author = {Zimmermann, Michal and de Lange, T.}, article_location = {LONDON}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.tcb.2013.09.003}, keywords = {53BP1; Rif1; PTIP; NHEJ; HDR; PARPi; telomere; CSR; V(D)J; BRCA1; resection}, language = {eng}, issn = {0962-8924}, journal = {TRENDS IN CELL BIOLOGY}, title = {53BP1: pro choice in DNA repair}, url = {http://ac.els-cdn.com/S0962892413001554/1-s2.0-S0962892413001554-main.pdf?_tid=66e12f66-bb3a-11e4-abe9-00000aacb360&acdnat=1424682203_f8bd4c3cd228cef3ed42bebd7ad4b631}, volume = {24}, year = {2014} }
TY - JOUR ID - 1227550 AU - Zimmermann, Michal - de Lange, T. PY - 2014 TI - 53BP1: pro choice in DNA repair JF - TRENDS IN CELL BIOLOGY VL - 24 IS - 2 SP - 108-117 EP - 108-117 PB - ELSEVIER SCIENCE LONDON SN - 09628924 KW - 53BP1 KW - Rif1 KW - PTIP KW - NHEJ KW - HDR KW - PARPi KW - telomere KW - CSR KW - V(D)J KW - BRCA1 KW - resection UR - http://ac.els-cdn.com/S0962892413001554/1-s2.0-S0962892413001554-main.pdf?_tid=66e12f66-bb3a-11e4-abe9-00000aacb360&acdnat=1424682203_f8bd4c3cd228cef3ed42bebd7ad4b631 L2 - http://ac.els-cdn.com/S0962892413001554/1-s2.0-S0962892413001554-main.pdf?_tid=66e12f66-bb3a-11e4-abe9-00000aacb360&acdnat=1424682203_f8bd4c3cd228cef3ed42bebd7ad4b631 N2 - The DNA damage response factor 53BP1 functions at the intersection of two major double strand break (DSB) repair pathways - promoting nonhomologous end-joining (NHEJ) and inhibiting homology-directed repair (HDR) - and integrates cellular inputs to ensure their timely execution in the proper cellular contexts. Recent work has revealed that 53BP1 controls 5' end resection at DNA ends, mediates synapsis of DNA ends, promotes the mobility of damaged chromatin, improves DSB repair in heterochromatic regions, and contributes to lethal mis-repair of DSBs in BRCA1-deficient cells. Here we review these aspects of 53BP1 and discuss new data revealing how 53BP1 is loaded onto chromatin and uses its interacting factors Rif1 and PTIP to promote NHEJ and inhibit HDR. ER -
ZIMMERMANN, Michal and T. DE LANGE. 53BP1: pro choice in DNA repair. \textit{TRENDS IN CELL BIOLOGY}. LONDON: ELSEVIER SCIENCE LONDON, 2014, vol.~24, No~2, p.~108-117. ISSN~0962-8924. Available from: https://dx.doi.org/10.1016/j.tcb.2013.09.003.
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